{"id":"W2942808525","doi":"10.1097/j.pain.0000000000001589","title":"Reduced excitatory neurotransmitter levels in anterior insulae are associated with abdominal pain in irritable bowel syndrome","year":2019,"lang":"en","type":"article","venue":"Pain","topic":"Music Therapy and Health","field":"Psychology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital; National Institutes of Health; Centre d'Imagerie BioMédicale; Knut och Alice Wallenbergs Stiftelse; Deutsche Forschungsgemeinschaft","keywords":"Irritable bowel syndrome; Neurotransmitter; Medicine; Internal medicine; Glutamate receptor; Visceral pain; Excitatory postsynaptic potential; gamma-Aminobutyric acid; Abdominal pain; Inhibitory postsynaptic potential; Glutamine; Psychology; Nociception; Chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001455597,0.0003962224,0.0002795649,0.0005219554,0.0001909242,0.0002779183,0.0001425361,0.0002670506,0.001664927],"category_scores_gemma":[0.000903393,0.0002002163,0.0002117115,0.0003312471,0.0003220015,0.0001210105,0.0002944663,0.0002509551,0.0001352649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001390324,"about_ca_system_score_gemma":0.00009944181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001531904,"about_ca_topic_score_gemma":0.00183137,"domain_scores_codex":[0.9999216,0.00001748541,0.00001191512,0.00001996633,0.00001646971,0.00001260303],"domain_scores_gemma":[0.9996365,0.00006305637,0.0001965515,0.00002447468,0.00002483564,0.00005463188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00178925,0.00009632247,0.9665781,0.00008668001,0.0002078376,0.001180931,0.0002514986,0.0001177831,0.02262542,0.00004508743,0.0001023572,0.006918699],"study_design_scores_gemma":[0.00000417364,0.00005330687,0.9992181,0.000002552763,0.00001554322,0.0004241655,0.00004007866,0.0000440314,0.0001579448,0.00001406448,0.00002470642,0.000001389502],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995062,0.0001904004,0.00007163121,0.00001720107,0.000002620608,0.000003191603,0.00005764442,0.000003450024,0.0001476609],"genre_scores_gemma":[0.9996275,0.00008881759,0.0001002919,0.00001361523,0.000004630612,0.000003982271,0.00008300378,0.000001473661,0.000076738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001664927,"threshold_uncertainty_score":0.005569756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02639882848550673,"score_gpt":0.2824938362642153,"score_spread":0.2560950077787086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}