{"id":"W2942844979","doi":"10.1021/acs.jmedchem.9b00349","title":"Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias","year":2019,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada Research Chairs; Deutsche Forschungsgemeinschaft","keywords":"Chemistry; Agonist; Partial agonist; Antagonist; Isoprenaline; Stereochemistry; Ligand (biochemistry); G protein-coupled receptor; Intrinsic activity; Receptor; Arrestin; Biochemistry; Internal medicine; Stimulation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000917772,0.0002827276,0.0002198995,0.0001182606,0.00009420094,0.0002515168,0.0001846396,0.0002475702,0.001246232],"category_scores_gemma":[0.0001599979,0.0001556234,0.0001875995,0.0001228968,0.0001302485,0.0001086368,0.0001845389,0.0002444788,0.000561955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002343855,"about_ca_system_score_gemma":0.0001371554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002995104,"about_ca_topic_score_gemma":0.0005768077,"domain_scores_codex":[0.9998783,0.00002323435,0.000008980949,0.00003281281,0.00002287726,0.00003377095],"domain_scores_gemma":[0.9999217,0.00001947999,0.00002051497,0.000008982178,0.000009928825,0.00001951174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006885431,0.00001137253,0.0001284965,0.00001711694,0.000005543396,0.00004885575,0.00001113859,0.0001616974,0.998485,0.00009520951,0.00001727277,0.0009494235],"study_design_scores_gemma":[0.00002080215,0.0004541253,0.001167445,0.000003425489,0.00002194157,0.0001736712,0.00001567793,0.0009084113,0.9947595,0.00003105494,0.002435722,0.00000822248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942729,0.000461607,0.003172825,0.00005908346,0.00001831567,0.00003478625,0.0001284285,0.00006861761,0.001783481],"genre_scores_gemma":[0.9937735,0.0002814941,0.004248387,0.0001091506,0.000008392334,0.00003419935,0.0001747643,0.00001738135,0.001352642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001246232,"threshold_uncertainty_score":0.004169106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007380042904262532,"score_gpt":0.2186480947568474,"score_spread":0.2112680518525849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}