{"id":"W2942931819","doi":"10.1164/rccm.201812-2275oc","title":"Multicenter Preclinical Validation of BET Inhibition for the Treatment of Pulmonary Arterial Hypertension","year":2019,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada); Université Laval","funders":"Hartstichting; Lung Foundation Netherlands; Nederlandse Federatie van Universitair Medische Centra; ZonMw; Koninklijke Nederlandse Akademie van Wetenschappen","keywords":"Medicine; BET inhibitor; Pulmonary hypertension; Bromodomain; Pulmonary artery; Pulmonary artery banding; Hypoxia (environmental); Cancer research; Lung; Downregulation and upregulation; Pathology; Cardiology; Internal medicine; Pharmacology; Epigenetics; Biology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000192383,0.00006878885,0.0002250236,0.000032252,0.00002369516,0.000002366438,0.00003931787,0.00003872545,0.00001357848],"category_scores_gemma":[0.0002794862,0.00003970715,0.00008115437,0.00003685112,0.0003897626,0.000006435799,0.000008835465,0.00003774013,1.66537e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007189787,"about_ca_system_score_gemma":0.00003310829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003576223,"about_ca_topic_score_gemma":4.27193e-7,"domain_scores_codex":[0.9992624,0.00008854427,0.0003596087,0.00009456922,0.000127543,0.0000673684],"domain_scores_gemma":[0.9991295,0.0001707303,0.0001884164,0.0001085927,0.0003487809,0.0000540244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001905358,0.0001950507,0.006494769,0.00007182451,0.00004527122,0.000002703254,0.0002024312,0.000004278034,0.9085024,0.00005204176,0.0001383626,0.08238552],"study_design_scores_gemma":[0.003885689,0.03640768,0.007844063,0.0002204839,0.0002432285,0.00003695875,0.003866822,0.00005049576,0.9205181,0.00003867933,0.02677159,0.0001162391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962772,0.002015649,0.0006796075,0.0005814973,0.0002372974,0.0001713812,0.00001168267,8.380277e-7,0.00002486226],"genre_scores_gemma":[0.9989353,0.0001759444,0.0001489281,0.0002789743,0.0004344958,0.000004411997,0.00001204572,0.000005475205,0.000004464216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08226928,"threshold_uncertainty_score":0.1619211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02448535999328036,"score_gpt":0.3192936133253251,"score_spread":0.2948082533320447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}