{"id":"W2942931819","doi":"10.1164/rccm.201812-2275oc","title":"Multicenter Preclinical Validation of BET Inhibition for the Treatment of Pulmonary Arterial Hypertension","year":2019,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada); Université Laval","funders":"Hartstichting; Lung Foundation Netherlands; Nederlandse Federatie van Universitair Medische Centra; ZonMw; Koninklijke Nederlandse Akademie van Wetenschappen","keywords":"Medicine; BET inhibitor; Pulmonary hypertension; Bromodomain; Pulmonary artery; Pulmonary artery banding; Hypoxia (environmental); Cancer research; Lung; Downregulation and upregulation; Pathology; Cardiology; Internal medicine; Pharmacology; Epigenetics; Biology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001400216,0.001016905,0.001197343,0.0005851121,0.0005442062,0.000780582,0.0007740105,0.0009013286,0.003984368],"category_scores_gemma":[0.0004624856,0.0003551321,0.0006694465,0.0003413217,0.000500267,0.0005471332,0.0003247122,0.002460197,0.0009095923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006034367,"about_ca_system_score_gemma":0.0009955363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005264181,"about_ca_topic_score_gemma":0.001156363,"domain_scores_codex":[0.999448,0.0001629278,0.0000424824,0.00009781297,0.0001178423,0.0001309219],"domain_scores_gemma":[0.9994381,0.0000528951,0.0001011989,0.00007928962,0.0001127088,0.0002158812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02730349,0.01795364,0.001117334,0.0006721022,0.0002656122,0.0001921676,0.0001320595,0.001083934,0.9231987,0.0008020112,0.00201156,0.02526739],"study_design_scores_gemma":[0.02357529,0.2833185,0.008309497,0.0001380417,0.0008303932,0.0007574811,0.0001900736,0.002693951,0.6565567,0.0005654407,0.02300731,0.00005725218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822289,0.003756491,0.004521772,0.0005231057,0.0004547791,0.002398239,0.002644728,0.0002589798,0.003212916],"genre_scores_gemma":[0.9708081,0.004163512,0.006169253,0.0003841733,0.0001968945,0.003924611,0.004718977,0.00006330568,0.009571207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003984368,"threshold_uncertainty_score":0.01332903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02448535999328036,"score_gpt":0.3192936133253251,"score_spread":0.2948082533320447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}