{"id":"W2942980993","doi":"10.1002/path.5286","title":"Four‐jointed knock‐out delays renal failure in an ADPKD model with kidney injury","year":2019,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Research Executive Agency; Nierstichting; European Commission","keywords":"PKD1; Cyst; Autosomal dominant polycystic kidney disease; Kidney; Fibrosis; Kidney disease; Pathology; Nephrotoxicity; Polycystic kidney disease; Inflammation; Medicine; Acute kidney injury; Internal medicine; Biology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004057679,0.0006914203,0.0008511458,0.0006413904,0.0003456267,0.0005280534,0.000467243,0.000900067,0.002140031],"category_scores_gemma":[0.0001980582,0.0003252358,0.0005262012,0.0002497078,0.0005922489,0.0005635499,0.0003599562,0.001382578,0.0006008956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00036324,"about_ca_system_score_gemma":0.0004048238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006784823,"about_ca_topic_score_gemma":0.0009316981,"domain_scores_codex":[0.9996052,0.0000590019,0.00006506675,0.00009427605,0.000100142,0.00007638567],"domain_scores_gemma":[0.9996122,0.00003808698,0.0001271653,0.0000381992,0.00002606413,0.0001583632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009799242,0.0003752515,0.0004448748,0.0001149747,0.00002457243,0.000336438,0.00005131376,0.0001919551,0.9949607,0.0003060219,0.000188957,0.002024957],"study_design_scores_gemma":[0.0002778386,0.003258933,0.009890026,0.00004249009,0.000106806,0.001498214,0.0001224735,0.003747276,0.9734728,0.0003360391,0.00720522,0.00004203746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884062,0.001562603,0.005955022,0.0003984618,0.000180514,0.00009678678,0.001203816,0.0003728264,0.001823868],"genre_scores_gemma":[0.9852271,0.001301914,0.004075899,0.0001629106,0.00003616237,0.000188623,0.001157393,0.00007978809,0.007770305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002140031,"threshold_uncertainty_score":0.007159173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009173404697898678,"score_gpt":0.2412778200948374,"score_spread":0.2321044153969387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}