{"id":"W2943000466","doi":"10.1016/j.stem.2019.04.008","title":"Pluripotency on Lockdown after Deletion of Three Transcription Regulators","year":2019,"lang":"en","type":"letter","venue":"Cell stem cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Induced pluripotent stem cell; Biology; Embryonic stem cell; Cell potency; Stem cell; Cell biology; Inner cell mass; Transcription factor; Genetics; Embryo; Gene; Embryogenesis; Blastocyst","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0002927073,0.0006335077,0.0005879585,0.0002604295,0.00006102102,0.00003968997,0.0006854208,0.001855971,0.0002129903],"category_scores_gemma":[0.000004099899,0.0006074473,0.0005422648,0.0001670852,0.0001359018,0.000007335012,0.0001470192,0.001070358,0.0005344377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009663002,"about_ca_system_score_gemma":0.000182029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003078532,"about_ca_topic_score_gemma":0.00001172761,"domain_scores_codex":[0.9963115,0.0002305878,0.0006569524,0.001166415,0.0008789952,0.0007555071],"domain_scores_gemma":[0.9978009,0.00003781201,0.00037415,0.001466818,0.0002244138,0.00009591068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003099589,0.0001395693,0.0002396624,0.001858028,0.00006389405,0.00007191294,0.00003113867,0.000128161,0.5626378,8.895744e-7,0.4337807,0.0007382376],"study_design_scores_gemma":[0.0006962327,0.0005875417,0.0001952955,0.0001268873,0.0000702881,0.000006104407,0.000008837336,0.00003941873,0.4761085,0.00001103836,0.5216426,0.0005073287],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9000024,0.01122011,0.002241179,0.02730541,0.00320139,0.004278314,0.0007151578,0.00009789727,0.05093809],"genre_scores_gemma":[0.8699895,0.0008530773,0.0001259588,0.03316388,0.002443591,0.0001557009,0.002212895,0.0003095303,0.09074584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08786181,"threshold_uncertainty_score":0.9996377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01129939734181663,"score_gpt":0.2110399500890986,"score_spread":0.199740552747282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}