{"id":"W2943000466","doi":"10.1016/j.stem.2019.04.008","title":"Pluripotency on Lockdown after Deletion of Three Transcription Regulators","year":2019,"lang":"en","type":"letter","venue":"Cell stem cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Induced pluripotent stem cell; Biology; Embryonic stem cell; Cell potency; Stem cell; Cell biology; Inner cell mass; Transcription factor; Genetics; Embryo; Gene; Embryogenesis; Blastocyst","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007030516,0.0004543577,0.0005634793,0.0002513444,0.0006931796,0.0009750535,0.0005662226,0.005735533,0.003739745],"category_scores_gemma":[0.001851093,0.0002636814,0.000693585,0.0001939646,0.001140982,0.0004394938,0.0004909709,0.004815683,0.001716955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000697441,"about_ca_system_score_gemma":0.0003380552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006719912,"about_ca_topic_score_gemma":0.001069356,"domain_scores_codex":[0.9994392,0.00009518132,0.00006311696,0.0001007049,0.0001619758,0.0001397771],"domain_scores_gemma":[0.9986656,0.0009110364,0.0001183237,0.0001125177,0.00008163969,0.0001108576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005811953,0.0004237168,0.005338738,0.0002808852,0.0001820346,0.07453553,0.0005762964,0.0008554159,0.6249259,0.01758012,0.1897398,0.07974961],"study_design_scores_gemma":[0.001335647,0.001635159,0.02052802,0.0001902098,0.0003985883,0.04118151,0.0006768358,0.004173646,0.4528649,0.02702193,0.4497403,0.0002532633],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.3282271,0.01037977,0.009350962,0.5471858,0.04241765,0.0002236071,0.001821814,0.001098925,0.05929437],"genre_scores_gemma":[0.6958109,0.004874755,0.001987597,0.2291994,0.01315689,0.000247104,0.0005954724,0.0003191798,0.05380873],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.005735533,"threshold_uncertainty_score":0.01251072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01129939734181663,"score_gpt":0.2110399500890986,"score_spread":0.199740552747282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}