{"id":"W2943061599","doi":"10.1038/s41598-019-43047-3","title":"Chemovirotherapeutic Treatment Using Camptothecin Enhances Oncolytic Measles Virus-Mediated Killing of Breast Cancer Cells","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Taipei Medical University Hospital; Canadian Institutes of Health Research; Beatrice Hunter Cancer Research Institute; Taipei Medical University; Ministry of Science and Technology, Taiwan; Government of Canada","keywords":"Oncolytic virus; Camptothecin; Measles virus; Breast cancer; Virotherapy; Medicine; Cancer research; Cancer; Combination therapy; Virus; Cancer cell; Ovarian cancer; Measles; Immunology; Pharmacology; Internal medicine; Biology; Vaccination","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006450022,0.0002165937,0.0002806801,0.000128017,0.0001188965,0.00006629348,0.0001819184,0.0001160717,0.0008286505],"category_scores_gemma":[0.00001038188,0.0001797389,0.000152969,0.0003181784,0.0002482164,0.000009918846,0.00005449174,0.00006151159,0.00003333644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001260856,"about_ca_system_score_gemma":0.0006437683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002698876,"about_ca_topic_score_gemma":0.0003012845,"domain_scores_codex":[0.9978377,0.00007926697,0.0004321482,0.0007771676,0.0004708742,0.0004028719],"domain_scores_gemma":[0.9984635,0.0000178869,0.0003104321,0.0008910389,0.0002010087,0.0001160968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002754936,0.0001443268,0.001761247,0.00002814969,0.000111384,0.0000117264,0.0001164747,0.000941449,0.9930587,3.072495e-7,0.00008102425,0.003469661],"study_design_scores_gemma":[0.0003437526,0.0003915789,0.0001240469,0.00004725083,0.00002604417,0.00002975139,0.00006290709,0.0005802608,0.9915724,0.00002810469,0.006596922,0.0001969184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956456,0.001522935,0.00003867952,0.00002758938,0.001996519,0.0005394775,0.00003221347,0.00001349441,0.0001834719],"genre_scores_gemma":[0.9961464,0.0002948317,0.000127467,0.00003500682,0.000122644,0.00003142639,0.00005294892,0.00003926247,0.00314997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006515898,"threshold_uncertainty_score":0.9073142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02153539000978096,"score_gpt":0.3067657083242631,"score_spread":0.2852303183144822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}