{"id":"W2943080317","doi":"10.1038/s41467-019-09786-7","title":"Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institutes of Health; National Cancer Institute; University of Toronto; Government of Ontario; University of Pittsburgh; Multiple Sclerosis Society; Alzheimer's Society; Compute Canada; U.S. Department of Veterans Affairs; Van Andel Research Institute; University of Miami; Scottish Rite Charitable Foundation of Canada; U.S. Department of Defense","keywords":"Enhancer; Epigenetics; Dopamine; Psychosis; Biology; DNA methylation; Schizophrenia (object-oriented programming); Methylation; Genetics; Neuroscience; Transcription factor; Gene; Gene expression; Psychology; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001007961,0.0002219689,0.0002035521,0.0005533954,0.0002061731,0.0001539522,0.0001055319,0.0001616227,0.001258519],"category_scores_gemma":[0.0002380718,0.0001248006,0.0001487582,0.0002391427,0.0002021354,0.00005548179,0.0002169425,0.0001589892,0.00009182211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001681909,"about_ca_system_score_gemma":0.0001148237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003267929,"about_ca_topic_score_gemma":0.005829812,"domain_scores_codex":[0.9999233,0.000009301585,0.000006340971,0.00002956777,0.00001612059,0.00001539988],"domain_scores_gemma":[0.9998552,0.00002019856,0.00006861785,0.00001143236,0.00001640181,0.00002807396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001280797,0.00002749518,0.3163514,0.00007211253,0.0001747652,0.001511391,0.0003312843,0.0001539892,0.6712589,0.0001067222,0.0001649538,0.008566148],"study_design_scores_gemma":[0.00001246542,0.00009649511,0.9667558,0.000007461775,0.0000726802,0.00358648,0.0001268247,0.0003392455,0.02841928,0.0001789493,0.0003969269,0.000007465071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987487,0.0002356592,0.0005335551,0.00001947388,0.000002825137,0.000003041962,0.000191311,0.00001090099,0.0002545859],"genre_scores_gemma":[0.9994708,0.0000609347,0.0001704017,0.00001008471,0.000001368008,0.000001726355,0.00011633,0.000003105707,0.0001652882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003267929,"threshold_uncertainty_score":0.00649786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009791230427121985,"score_gpt":0.2778370991636696,"score_spread":0.2680458687365476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}