{"id":"W2943080317","doi":"10.1038/s41467-019-09786-7","title":"Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institutes of Health; National Cancer Institute; University of Toronto; Government of Ontario; University of Pittsburgh; Multiple Sclerosis Society; Alzheimer's Society; Compute Canada; U.S. Department of Veterans Affairs; Van Andel Research Institute; University of Miami; Scottish Rite Charitable Foundation of Canada; U.S. Department of Defense","keywords":"Enhancer; Epigenetics; Dopamine; Psychosis; Biology; DNA methylation; Schizophrenia (object-oriented programming); Methylation; Genetics; Neuroscience; Transcription factor; Gene; Gene expression; Psychology; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001525098,0.0001112963,0.0001599291,0.00007914368,0.0000588454,0.000008481486,0.0003566633,0.0003153895,0.0001023143],"category_scores_gemma":[0.0001203309,0.0001000111,0.00005924877,0.0002057046,0.00005649127,0.000005773652,0.0001581,0.0002148779,0.000005797403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003507298,"about_ca_system_score_gemma":0.00002467036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000030085,"about_ca_topic_score_gemma":0.001443091,"domain_scores_codex":[0.9991785,0.0001311356,0.0002276367,0.0001941977,0.0001436756,0.0001249149],"domain_scores_gemma":[0.9985791,0.0001131429,0.0001799379,0.0009462078,0.0001526919,0.00002893761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008311628,0.0001786361,0.1080888,0.000009743066,0.00009130508,7.584715e-8,0.00008288887,0.00002995037,0.8899771,0.0001105072,0.000108188,0.001239698],"study_design_scores_gemma":[0.0005303468,0.0001000846,0.1742184,0.00004186253,0.00004205176,3.265193e-7,0.00001964511,0.0002742321,0.8213106,0.00003286219,0.003284202,0.0001453806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993798,0.003267755,0.0001685686,0.0003493819,0.00006106438,0.0002190562,0.00005624289,0.000006306491,0.00207363],"genre_scores_gemma":[0.9972647,0.0009460064,0.0009351101,0.00004183826,0.00001928618,0.00004222694,0.0003728544,0.00001711932,0.0003608434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06866648,"threshold_uncertainty_score":0.4078332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009791230427121985,"score_gpt":0.2778370991636696,"score_spread":0.2680458687365476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}