{"id":"W2943151208","doi":"10.1016/j.ccell.2019.03.014","title":"Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality","year":2019,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":354,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Cancer Institute; Leukemia and Lymphoma Society of Canada; University of Texas MD Anderson Cancer Center; U.S. Food and Drug Administration; National Institutes of Health; Ontario Ministry of Research, Innovation and Science; Canada Research Chairs; Princess Margaret Cancer Foundation; Ontario Institute for Cancer Research; Canadian Institutes of Health Research; Leukemia and Lymphoma Society; Novartis","keywords":"Proteolysis; Synthetic lethality; Biology; Cancer; Cancer cell; Lethality; Cell biology; Cell; Cancer research; Biochemistry; Gene; Genetics; Enzyme; DNA repair","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002094339,0.0004173633,0.0003693794,0.000440923,0.0002577261,0.0004362708,0.0002745389,0.0005959481,0.002337197],"category_scores_gemma":[0.0001886301,0.0002018157,0.0003341479,0.0003490951,0.00029821,0.0002219236,0.0004125277,0.001019805,0.0006690533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004596031,"about_ca_system_score_gemma":0.0003033659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001026345,"about_ca_topic_score_gemma":0.001522564,"domain_scores_codex":[0.9996765,0.00005968611,0.00003741978,0.00006410277,0.00009156073,0.00007087617],"domain_scores_gemma":[0.9996594,0.0001080166,0.00005894346,0.00007166104,0.00002410475,0.00007779223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002036251,0.00005446654,0.0002094367,0.00002936608,0.00001042928,0.0002696831,0.0000186867,0.0001958866,0.9975489,0.0003751327,0.000149403,0.0009349937],"study_design_scores_gemma":[0.00001601368,0.0002041312,0.001934791,0.000003379317,0.000009937015,0.0007184939,0.00002614367,0.001049025,0.9942502,0.00005854478,0.001725378,0.000003915346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853556,0.001627595,0.005925081,0.0003494823,0.0001013389,0.00007967271,0.002143824,0.0003273582,0.004089953],"genre_scores_gemma":[0.9948741,0.0003736789,0.001004722,0.00005558486,0.000007249021,0.00003229537,0.0007364574,0.00003725192,0.002878704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002337197,"threshold_uncertainty_score":0.007818699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015015105451309,"score_gpt":0.2520556147589593,"score_spread":0.2419054637044462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}