{"id":"W2943151208","doi":"10.1016/j.ccell.2019.03.014","title":"Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality","year":2019,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":354,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Cancer Institute; Leukemia and Lymphoma Society of Canada; University of Texas MD Anderson Cancer Center; U.S. Food and Drug Administration; National Institutes of Health; Ontario Ministry of Research, Innovation and Science; Canada Research Chairs; Princess Margaret Cancer Foundation; Ontario Institute for Cancer Research; Canadian Institutes of Health Research; Leukemia and Lymphoma Society; Novartis","keywords":"Proteolysis; Synthetic lethality; Biology; Cancer; Cancer cell; Lethality; Cell biology; Cell; Cancer research; Biochemistry; Gene; Genetics; Enzyme; DNA repair","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00008607528,0.0002477016,0.0002692127,0.00002437678,0.00007551953,0.00002286045,0.0002227041,0.0003863703,0.003050514],"category_scores_gemma":[0.00002596112,0.0002326332,0.0001469254,0.0001388688,0.00005971142,0.00001025197,0.00008468988,0.0001975073,0.0002517576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000111178,"about_ca_system_score_gemma":0.000344938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001822551,"about_ca_topic_score_gemma":0.00128366,"domain_scores_codex":[0.9983848,0.0001553091,0.0002486343,0.000676949,0.0001617872,0.0003725459],"domain_scores_gemma":[0.9990855,0.00002065416,0.0001698216,0.0004115518,0.0001787626,0.0001336867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003140282,0.0000739988,0.00289758,0.00004581411,0.00005169598,0.000001536576,0.0001611035,0.0000780028,0.9802122,0.000004460137,0.01580753,0.0003520575],"study_design_scores_gemma":[0.001266206,0.0002462155,0.0003993988,0.000008923706,0.00004853257,0.000001192843,0.0001068122,0.00001778789,0.8244922,0.0000101144,0.1731057,0.0002970101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703808,0.005870229,0.0002458741,0.000136938,0.004801437,0.000861446,0.0001760231,0.00003584415,0.01749137],"genre_scores_gemma":[0.9725993,0.002424352,0.0004254211,0.001325447,0.003018262,0.0005887925,0.0003695432,0.00006135572,0.01918751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1572981,"threshold_uncertainty_score":0.9978608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015015105451309,"score_gpt":0.2520556147589593,"score_spread":0.2419054637044462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}