{"id":"W2943155654","doi":"10.1186/s40425-019-0542-z","title":"Radiotherapy enhances responses of lung cancer to CTLA-4 blockade","year":2019,"lang":"en","type":"letter","venue":"Journal for ImmunoTherapy of Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Institute for Health and Care Research; Cancer Research UK","keywords":"Abscopal effect; Ipilimumab; Medicine; Radiation therapy; Immunotherapy; CTLA-4; Immune system; Lung cancer; Oncology; Clinical trial; Blockade; Immune checkpoint; Biological response modifiers; Immunology; Internal medicine; T cell; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008236044,0.0007393594,0.002215614,0.0009219878,0.0001567326,0.00006215033,0.0007298928,0.0009065603,0.002801641],"category_scores_gemma":[0.00005479329,0.000590315,0.001611319,0.0005384806,0.0002610178,0.0001542665,0.00002551837,0.001419563,0.000001999756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009572197,"about_ca_system_score_gemma":0.002366094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008140582,"about_ca_topic_score_gemma":0.00002738576,"domain_scores_codex":[0.9955165,0.0001663781,0.001775642,0.0005689358,0.001162521,0.000809987],"domain_scores_gemma":[0.9955859,0.0005334981,0.00197683,0.000825885,0.0009704651,0.0001074304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02588844,0.00008187284,0.0008358798,0.001109008,0.004657603,0.00001488114,0.0006376718,0.00002408191,0.3803986,0.000001088378,0.5543296,0.03202122],"study_design_scores_gemma":[0.007248755,0.001961302,0.001022338,0.003730536,0.0004806043,0.00009440474,0.00003301748,0.00002332816,0.1505041,0.00002419644,0.8343296,0.0005478298],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1048535,0.2972418,0.0007210267,0.5836886,0.008424036,0.003674182,0.001152526,0.00004810258,0.0001963459],"genre_scores_gemma":[0.003746053,0.2386115,0.003697912,0.661497,0.01546863,0.0009872977,0.00007727138,0.0006953647,0.07521895],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2799999,"threshold_uncertainty_score":0.9996548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02045189570884703,"score_gpt":0.3664423344238244,"score_spread":0.3459904387149774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}