{"id":"W2943155654","doi":"10.1186/s40425-019-0542-z","title":"Radiotherapy enhances responses of lung cancer to CTLA-4 blockade","year":2019,"lang":"en","type":"letter","venue":"Journal for ImmunoTherapy of Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Institute for Health and Care Research; Cancer Research UK","keywords":"Abscopal effect; Ipilimumab; Medicine; Radiation therapy; Immunotherapy; CTLA-4; Immune system; Lung cancer; Oncology; Clinical trial; Blockade; Immune checkpoint; Biological response modifiers; Immunology; Internal medicine; T cell; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005869052,0.0002258061,0.0004598737,0.0001640635,0.0002408798,0.0004382707,0.0001531832,0.001567092,0.001764492],"category_scores_gemma":[0.001592427,0.0001062992,0.0003690344,0.000107438,0.0002265244,0.0001884753,0.0001427653,0.001159087,0.0006861773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004549493,"about_ca_system_score_gemma":0.0001587162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000206825,"about_ca_topic_score_gemma":0.00028924,"domain_scores_codex":[0.9997291,0.0001186273,0.00002064557,0.00002879796,0.00004849676,0.00005433732],"domain_scores_gemma":[0.9991811,0.0005664412,0.00005334853,0.0000553006,0.00007534168,0.00006837086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01910534,0.003030035,0.04551101,0.0014425,0.0002164364,0.04979002,0.0006488665,0.002466115,0.4507549,0.002879266,0.07842618,0.3457294],"study_design_scores_gemma":[0.004089761,0.04576907,0.1977576,0.0001720472,0.0004140628,0.07607812,0.0004357039,0.01011489,0.3358104,0.00516822,0.3240822,0.0001079904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.9093236,0.01203,0.001528597,0.04269432,0.002898415,0.0003231678,0.0002789031,0.000453207,0.03046978],"genre_scores_gemma":[0.9720005,0.002682108,0.0006439235,0.0143947,0.002759357,0.0001037458,0.0001785266,0.00003485768,0.007202368],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.001764492,"threshold_uncertainty_score":0.005902886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02045189570884703,"score_gpt":0.3664423344238244,"score_spread":0.3459904387149774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}