{"id":"W2943169182","doi":"10.1038/s41588-019-0398-7","title":"SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development","year":2019,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":279,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Tsinghua University","keywords":"Epigenome; Biology; H3K4me3; Genomic imprinting; DNA methylation; Oocyte; Cell biology; Genetics; Epigenetics; Histone methylation; Histone H3; Chromatin; Embryo; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001303899,0.000378482,0.0002240418,0.0003465028,0.0002944809,0.0007425644,0.000499681,0.0003662043,0.00219083],"category_scores_gemma":[0.0001892506,0.0002646284,0.0002048437,0.0002096565,0.000372613,0.0003202314,0.0006419023,0.0005294641,0.0005078578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006650821,"about_ca_system_score_gemma":0.0002466422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007597611,"about_ca_topic_score_gemma":0.002098885,"domain_scores_codex":[0.9998554,0.00001715123,0.00000689604,0.00003352169,0.00005588865,0.00003114718],"domain_scores_gemma":[0.9998833,0.00002163857,0.00002826105,0.00001284698,0.00001430338,0.00003969886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000225355,0.00001230331,0.00175826,0.00005012636,0.00001593984,0.0001923362,0.00002711717,0.0002601009,0.9893544,0.002457973,0.0004313288,0.005214811],"study_design_scores_gemma":[0.00003349513,0.00006719869,0.03402057,0.00001635926,0.00002888099,0.0007477495,0.00009515494,0.003405474,0.9435784,0.001277582,0.0167067,0.00002236996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9351506,0.01517754,0.02044079,0.001177756,0.000369436,0.00003374046,0.002585685,0.0005492592,0.02451529],"genre_scores_gemma":[0.9846871,0.002024036,0.002685703,0.0001707614,0.00003219727,0.00001995056,0.001148702,0.00008655392,0.009144933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00219083,"threshold_uncertainty_score":0.007329047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00424101838882649,"score_gpt":0.2258793797423996,"score_spread":0.2216383613535731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}