{"id":"W2943169182","doi":"10.1038/s41588-019-0398-7","title":"SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development","year":2019,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":279,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Tsinghua University","keywords":"Epigenome; Biology; H3K4me3; Genomic imprinting; DNA methylation; Oocyte; Cell biology; Genetics; Epigenetics; Histone methylation; Histone H3; Chromatin; Embryo; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002809788,0.0001637364,0.0001111525,0.00003182547,0.0001213546,0.00005803531,0.0002203393,0.0002931857,0.00001769308],"category_scores_gemma":[0.00001806847,0.0001259199,0.00004215485,0.0000569517,0.00004179191,0.000001773368,0.0002447123,0.0002193283,0.00002585472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001650226,"about_ca_system_score_gemma":0.00007331377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002166769,"about_ca_topic_score_gemma":0.00001547253,"domain_scores_codex":[0.9990318,0.00003841162,0.0001916266,0.0003398481,0.0001416947,0.0002566325],"domain_scores_gemma":[0.9993905,0.00001342717,0.00009700987,0.0003672359,0.00007289296,0.0000589539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001394833,0.000007748839,0.1317593,0.00002171324,0.00004438055,5.649521e-7,0.00008116786,0.0002222621,0.8540437,0.00003038536,0.00003142891,0.01374341],"study_design_scores_gemma":[0.0001957365,0.00005139449,0.389033,0.000006503786,0.00001001387,0.000004256985,0.00002308368,0.00009688033,0.5400385,0.0001098239,0.07028005,0.0001507239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785703,0.02010823,0.0001255344,0.0001040305,0.0003125484,0.0002339709,0.000004164985,0.000008705686,0.0005324864],"genre_scores_gemma":[0.9943403,0.001106365,0.002883204,0.0001674422,0.0002276722,0.000006601388,0.00003658233,0.00002964367,0.001202197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3140051,"threshold_uncertainty_score":0.5134867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00424101838882649,"score_gpt":0.2258793797423996,"score_spread":0.2216383613535731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}