{"id":"W2943239879","doi":"10.1039/c9md00088g","title":"Anthranilic amide and imidazobenzothiadiazole compounds disrupt<i>Mycobacterium tuberculosis</i>membrane potential","year":2019,"lang":"en","type":"article","venue":"MedChemComm","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Eli Lilly and Company; Bill and Melinda Gates Foundation","keywords":"Amide; Mycobacterium tuberculosis; Chemistry; Anthranilic acid; Membrane; Combinatorial chemistry; Tuberculosis; Stereochemistry; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168194,0.0003095944,0.0001758446,0.0001204655,0.0001701321,0.0001544922,0.000353202,0.0004298503,0.006338189],"category_scores_gemma":[0.0001767885,0.0001366182,0.0001446614,0.0001953781,0.0002019135,0.0002008187,0.00009806433,0.0005990315,0.001117696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002682644,"about_ca_system_score_gemma":0.0002483541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001170866,"about_ca_topic_score_gemma":0.001700995,"domain_scores_codex":[0.9998688,0.0000224927,0.000007613315,0.00002250774,0.00003786422,0.00004071535],"domain_scores_gemma":[0.9998933,0.00003236113,0.00002460405,0.000008194014,0.00001524839,0.00002633929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004388771,0.0000525234,0.0001157051,0.0001166603,0.000009074134,0.00007218118,0.00001629203,0.00009609809,0.9960806,0.0001962535,0.0009175491,0.001888214],"study_design_scores_gemma":[0.00005002763,0.000699021,0.00210624,0.00001057858,0.0000100229,0.0001640335,0.00003270021,0.0005214908,0.9923286,0.00007245787,0.003999574,0.000005130974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9535866,0.009370941,0.00666794,0.001272824,0.0008261899,0.0001352889,0.003050767,0.0005022027,0.02458723],"genre_scores_gemma":[0.9765195,0.004020273,0.004977931,0.0002699114,0.00006658317,0.00006316823,0.002724764,0.00003520754,0.01132261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006338189,"threshold_uncertainty_score":0.02120334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01091459192144895,"score_gpt":0.2817275110446603,"score_spread":0.2708129191232113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}