{"id":"W2943256289","doi":"10.1016/j.canlet.2019.04.026","title":"p21-Activated kinase 3 promotes cancer stem cell phenotypes through activating the Akt-GSK3β-β-catenin signaling pathway in pancreatic cancer cells","year":2019,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"China Scholarship Council; Public Health Agency of Canada","keywords":"Protein kinase B; Cancer research; Cancer stem cell; Pancreatic cancer; Gene knockdown; Catenin; Cancer cell; Gene silencing; Cell growth; PAK1; Cancer; Kinase; Signal transduction; Chemistry; Biology; Cell biology; Stem cell; Wnt signaling pathway; Cell culture; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000413466,0.0004021616,0.000890645,0.0001261235,0.0001820248,0.00004919935,0.000317113,0.000186178,0.001419462],"category_scores_gemma":[0.00002892502,0.0002778093,0.0001320578,0.0006258004,0.0002649245,0.0002314938,0.00009356131,0.0008475487,0.00008457171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009781568,"about_ca_system_score_gemma":0.0008720994,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009292113,"about_ca_topic_score_gemma":0.0002732007,"domain_scores_codex":[0.9971009,0.0002667945,0.0005246895,0.0006620476,0.0005313803,0.000914169],"domain_scores_gemma":[0.9984128,0.0005237675,0.0002931935,0.0004835313,0.0001369324,0.0001497922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003865807,0.0001051855,0.1422446,0.0005042145,0.0002091963,0.0000539824,0.004064819,0.0007844946,0.8464074,0.00001248534,0.001032242,0.004194802],"study_design_scores_gemma":[0.003114326,0.0001739971,0.01206084,0.001516427,0.0001869276,0.000004647297,0.001280543,0.001178738,0.9768323,0.00002585679,0.003187,0.0004384497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837801,0.003262012,0.00007046031,0.009320045,0.0004626779,0.001806642,0.00004233329,0.00007485624,0.001180816],"genre_scores_gemma":[0.9907838,0.0005094752,0.000277598,0.004748726,0.0004311427,0.001074399,0.00001203073,0.0000854257,0.002077384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1304248,"threshold_uncertainty_score":0.9999674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03704123760492299,"score_gpt":0.3114036085956929,"score_spread":0.2743623709907699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}