{"id":"W2943295610","doi":"10.1111/all.13850","title":"The clinical benefit of mepolizumab replacing omalizumab in uncontrolled severe eosinophilic asthma","year":2019,"lang":"en","type":"article","venue":"Allergy","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"GlaxoSmithKline","keywords":"Mepolizumab; Omalizumab; Medicine; Exacerbation; Asthma; Population; Clinical endpoint; Internal medicine; Physical therapy; Pediatrics; Clinical trial; Eosinophil; Immunology; Immunoglobulin E; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008945675,0.0004014715,0.0008682784,0.0001487925,0.0001374918,0.0004600359,0.0002797927,0.0004160602,0.001191699],"category_scores_gemma":[0.001028716,0.0001789317,0.0005117784,0.0001403548,0.0003255491,0.0003400484,0.0002075646,0.00107233,0.0001586603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002486572,"about_ca_system_score_gemma":0.0003017851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002389754,"about_ca_topic_score_gemma":0.0005675044,"domain_scores_codex":[0.9997627,0.0001114919,0.00002164804,0.0000370382,0.00003425179,0.00003287711],"domain_scores_gemma":[0.9995623,0.0001493793,0.0001391072,0.00002733863,0.00001618224,0.0001056579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7401389,0.008799996,0.02268303,0.0008617108,0.001028451,0.0003020577,0.0001535851,0.001637541,0.06256887,0.0001654475,0.001330381,0.1603301],"study_design_scores_gemma":[0.3231286,0.4677525,0.1879264,0.0001664056,0.00148294,0.0009987891,0.0001516706,0.003046841,0.01079683,0.0003352187,0.004149043,0.00006468732],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969391,0.002417587,0.00008713154,0.0001277344,0.00003759508,0.00005790008,0.00005891905,0.00001199307,0.0002622149],"genre_scores_gemma":[0.9988682,0.0005247843,0.0001646374,0.00009413154,0.00005931601,0.00004599341,0.00008563773,0.000002540205,0.0001547514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001191699,"threshold_uncertainty_score":0.00473094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01248344375094616,"score_gpt":0.2917586319689213,"score_spread":0.2792751882179751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}