{"id":"W2943342912","doi":"10.1128/mcb.00489-18","title":"Isoginkgetin, a Natural Biflavonoid Proteasome Inhibitor, Sensitizes Cancer Cells to Apoptosis via Disruption of Lysosomal Homeostasis and Impaired Protein Clearance","year":2019,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Proteasome; Cell biology; Biology; Autophagy; Protein degradation; Programmed cell death; Proteasome inhibitor; Endoplasmic-reticulum-associated protein degradation; Bortezomib; TFEB; Apoptosis; Unfolded protein response; Endoplasmic reticulum; Lysosome; Biochemistry; Immunology; Multiple myeloma","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009904056,0.0002140324,0.0001813275,0.0002558503,0.0000913457,0.000185151,0.0001514668,0.0001754224,0.0004378517],"category_scores_gemma":[0.00006812903,0.00004445522,0.0001488938,0.0001285607,0.0001660154,0.0001136579,0.0000888833,0.0002772191,0.0001075529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003752105,"about_ca_system_score_gemma":0.0001331389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004115699,"about_ca_topic_score_gemma":0.0006689095,"domain_scores_codex":[0.9999462,0.00001332096,0.000004373974,0.00001009171,0.00001540688,0.00001061112],"domain_scores_gemma":[0.9999626,0.000006438734,0.00001088566,0.000005913074,0.000005699285,0.000008535892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001836421,0.00003553589,0.0002341212,0.00005264737,0.000007191435,0.0000914755,0.0000105665,0.0001142009,0.9939977,0.000153297,0.00005977534,0.005059819],"study_design_scores_gemma":[0.00003235571,0.0004624458,0.003484887,0.000006078587,0.00001843959,0.0005290414,0.00001306239,0.0005811172,0.9897459,0.0001092465,0.005012889,0.00000460996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774173,0.01366736,0.005548838,0.000207884,0.00005335056,0.00006124809,0.0002190061,0.0001802504,0.002644732],"genre_scores_gemma":[0.99429,0.002609179,0.001635444,0.00008002429,0.00001114407,0.0000163533,0.0001904609,0.000008593867,0.001158742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004378517,"threshold_uncertainty_score":0.002722383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004633895976654081,"score_gpt":0.2180537553721388,"score_spread":0.2134198593954847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}