{"id":"W2943385176","doi":"10.3389/fnins.2019.00404","title":"Overcoming Resistance to Selective Serotonin Reuptake Inhibitors: Targeting Serotonin, Serotonin-1A Receptors and Adult Neuroplasticity","year":2019,"lang":"en","type":"review","venue":"Frontiers in Neuroscience","topic":"Treatment of Major Depression","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"Serotonin; 5-HT receptor; Serotonin Uptake Inhibitors; Neuroplasticity; Neuroscience; Receptor; Serotonin reuptake inhibitor; Pharmacology; Medicine; Biology; Internal medicine; Fluoxetine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006189861,0.00107714,0.002658624,0.0009489427,0.0003152346,0.0001709396,0.0006783038,0.0004932242,0.000007946085],"category_scores_gemma":[0.002782592,0.0009362517,0.0003077094,0.002230457,0.000313372,0.0004566691,0.0005589878,0.001587975,0.0000296378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008434809,"about_ca_system_score_gemma":0.0005827869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002471081,"about_ca_topic_score_gemma":0.00001340244,"domain_scores_codex":[0.9933158,0.0005617877,0.001212491,0.002634017,0.00110537,0.001170511],"domain_scores_gemma":[0.997296,0.0003032697,0.0006749743,0.0009598987,0.0001944273,0.0005714204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002750684,0.001646357,0.1581086,0.06983873,0.0002367538,0.002267224,0.002566448,0.000218235,0.003199518,0.0001137772,0.2235698,0.5354838],"study_design_scores_gemma":[0.00123489,0.0007414249,0.001783721,0.02495196,0.0003949384,0.000108914,0.00006573665,0.0002077847,0.0005474096,0.00001153167,0.9690136,0.0009381258],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008844102,0.9662399,0.0006634966,0.0003428176,0.008325602,0.0139657,0.0001062401,0.0003807803,0.001131351],"genre_scores_gemma":[0.0007743544,0.9760451,0.01705185,0.0007322265,0.0002883922,0.0009040306,0.00003650294,0.0002589654,0.003908622],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7454438,"threshold_uncertainty_score":0.9993088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02586158067344464,"score_gpt":0.3005157710568986,"score_spread":0.274654190383454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}