{"id":"W2943385176","doi":"10.3389/fnins.2019.00404","title":"Overcoming Resistance to Selective Serotonin Reuptake Inhibitors: Targeting Serotonin, Serotonin-1A Receptors and Adult Neuroplasticity","year":2019,"lang":"en","type":"review","venue":"Frontiers in Neuroscience","topic":"Treatment of Major Depression","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"Serotonin; 5-HT receptor; Serotonin Uptake Inhibitors; Neuroplasticity; Neuroscience; Receptor; Serotonin reuptake inhibitor; Pharmacology; Medicine; Biology; Internal medicine; Fluoxetine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002129858,0.000459103,0.0005563516,0.0004122983,0.0001388047,0.0004316597,0.0003871481,0.0006945778,0.001954275],"category_scores_gemma":[0.0001449143,0.0001343676,0.000442544,0.0002628,0.0002066712,0.0005211972,0.00026329,0.0009137074,0.0007792235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002873572,"about_ca_system_score_gemma":0.0002930349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005240486,"about_ca_topic_score_gemma":0.001979897,"domain_scores_codex":[0.9999343,0.00001240113,0.000008835988,0.00001488868,0.00001627336,0.0000132775],"domain_scores_gemma":[0.9999601,0.00001126925,0.00001250938,0.000001562069,0.000008586418,0.000005967318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004713164,0.0002221833,0.0009987497,0.02141246,0.0002823837,0.0008895436,0.0002498624,0.001138089,0.1301382,0.008438512,0.0181285,0.8176302],"study_design_scores_gemma":[0.0002253141,0.003094269,0.01058696,0.003741579,0.0009308492,0.005796431,0.0002256674,0.001759068,0.05884206,0.006668836,0.9080484,0.00008057868],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008744954,0.9834548,0.002167353,0.00170908,0.0003941184,0.00005302912,0.0001186485,0.00006722836,0.003290906],"genre_scores_gemma":[0.02896755,0.9635863,0.002142606,0.001264226,0.0003635673,0.00005221156,0.0001648768,0.000007911754,0.003450582],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001954275,"threshold_uncertainty_score":0.006537735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02586158067344464,"score_gpt":0.3005157710568986,"score_spread":0.274654190383454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}