{"id":"W2943412515","doi":"10.3747/co.26.4345","title":"Review of Bruton Tyrosine Kinase Inhibitors for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma","year":2019,"lang":"en","type":"review","venue":"Current Oncology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia; Health Sciences Centre; Sunnybrook Health Science Centre; Fluidigm (Canada); BC Cancer Agency; Foothills Medical Centre; Impact; University of Calgary","funders":"AstraZeneca Canada; AstraZeneca","keywords":"Mantle cell lymphoma; Medicine; Bruton's tyrosine kinase; Ibrutinib; Tyrosine kinase; Refractory (planetary science); Cancer research; Lymphoma; Oncology; Internal medicine; Bioinformatics; Leukemia; Biology; Chronic lymphocytic leukemia; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002781396,0.0005770766,0.004196366,0.0001669222,0.00004704272,0.000003639373,0.0002089676,0.0003618023,0.0001759854],"category_scores_gemma":[0.0001339954,0.0002743476,0.001560759,0.0002812388,0.0001542079,0.00002411472,0.00005363097,0.00009607728,0.00006464798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001712637,"about_ca_system_score_gemma":0.002174059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002778204,"about_ca_topic_score_gemma":0.000006473491,"domain_scores_codex":[0.9972513,0.00021723,0.001430916,0.0005239237,0.0002395088,0.0003371753],"domain_scores_gemma":[0.9953129,0.001799639,0.001545491,0.000978632,0.0002371459,0.0001261561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001654554,0.008805037,0.00002874405,0.2003561,0.0004055548,0.00001852421,0.0000389827,1.984303e-8,0.000001000902,0.00002106939,0.01883586,0.7713236],"study_design_scores_gemma":[0.006371424,0.008594963,0.00002216423,0.1038357,0.01256142,0.00005321014,0.00001196778,0.000001437939,0.0001092536,0.000001427971,0.8682516,0.0001854173],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006154801,0.9899322,0.000002522426,0.0001546354,0.002432425,0.00663493,0.0003652625,0.00001810073,0.0003983828],"genre_scores_gemma":[0.00002436797,0.9961766,0.00008358996,0.00007709431,0.000400354,0.001635992,0.0007227405,0.00006692372,0.0008123231],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8494158,"threshold_uncertainty_score":0.9999709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1938884262347178,"score_gpt":0.4498050806863323,"score_spread":0.2559166544516145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}