{"id":"W2943421228","doi":"10.1093/annonc/mdz136","title":"Germline-focussed analysis of tumour-only sequencing: recommendations from the ESMO Precision Medicine Working Group","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":238,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"National Cancer Institute; National Institutes of Health; Cancer Research UK; European Society for Medical Oncology; University of Arizona Cancer Center; Memorial Sloan-Kettering Cancer Center","keywords":"Medicine; Precision medicine; Germline; Oncology; Medical physics; Internal medicine; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.101325,0.002284462,0.00348702,0.005372759,0.001574907,0.004980979,0.01021522,0.02054919,0.004991843],"category_scores_gemma":[0.1528121,0.001431501,0.005191084,0.002459494,0.003986344,0.005200295,0.004033186,0.01877289,0.004658492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002630868,"about_ca_system_score_gemma":0.01334758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01456773,"about_ca_topic_score_gemma":0.01933696,"domain_scores_codex":[0.961971,0.01704196,0.006470142,0.003901863,0.009008205,0.001606706],"domain_scores_gemma":[0.8124506,0.09513327,0.007129111,0.008386047,0.06599903,0.01090195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001329929,0.0003553555,0.01312444,0.004448542,0.0009924066,0.001101219,0.001483973,0.004185439,0.005539177,0.01307109,0.5848637,0.3695048],"study_design_scores_gemma":[0.00109829,0.0009816561,0.03150915,0.02887705,0.002322925,0.003318845,0.001569273,0.007247717,0.008169121,0.06384485,0.8505948,0.0004662957],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"methods","genre_scores_codex":[0.0059822,0.06916586,0.08640098,0.7872665,0.0183357,0.001243211,0.003627621,0.00270579,0.02527219],"genre_scores_gemma":[0.04829393,0.04720636,0.2800691,0.5836667,0.01908696,0.003823583,0.005217405,0.001552074,0.01108389],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.101325,"threshold_uncertainty_score":0.535864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06291957842298881,"score_gpt":0.3538099618176872,"score_spread":0.2908903833946984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}