{"id":"W2943497585","doi":"10.1016/j.stemcr.2019.04.005","title":"Human Embryonic Stem Cell-Derived Cardiomyocytes Regenerate the Infarcted Pig Heart but Induce Ventricular Tachyarrhythmias","year":2019,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":318,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Toronto General Hospital; Toronto Rehabilitation Institute; Sunnybrook Health Science Centre; Health Sciences Centre","funders":"Department of Family and Community Medicine, University of Toronto; Peter Munk Cardiac Centre, University Health Network; Toronto General Hospital Research Institute, University Health Network; Canada First Research Excellence Fund; Ontario Institute for Regenerative Medicine; Canada Foundation for Innovation; Sunnybrook Research Institute; University Health Network","keywords":"Biology; Embryonic stem cell; Stem cell; Internal medicine; Myocyte; Cardiology; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006162233,0.0004578236,0.0009718886,0.0001455035,0.0003783846,0.00005124496,0.0001243435,0.0003387062,0.0001437697],"category_scores_gemma":[0.00001023401,0.0003315073,0.0006207122,0.0004568826,0.0001304816,0.0001062951,0.0001554785,0.0007829439,0.0002761816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000180561,"about_ca_system_score_gemma":0.0003957736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006754226,"about_ca_topic_score_gemma":0.000002137607,"domain_scores_codex":[0.9966858,0.0003500669,0.000734999,0.0008903621,0.0005663348,0.0007724388],"domain_scores_gemma":[0.9972496,0.00009217605,0.000497659,0.00167397,0.0002505878,0.0002359983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001131047,0.00008929126,0.004803568,0.0002306692,0.0002812745,0.01430273,0.0002773948,0.0006257697,0.9740186,0.00003365384,0.004731289,0.0004926968],"study_design_scores_gemma":[0.001504888,0.0006731626,0.02069711,0.0001421326,0.0004557343,0.01441104,0.0005413503,0.00004340823,0.9290933,0.00004136224,0.03175462,0.0006418849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851395,0.004788153,0.000005713091,0.0005289225,0.001097106,0.001432916,0.000006069971,0.0001806174,0.006821029],"genre_scores_gemma":[0.9712849,0.00006809778,0.00002122863,0.0005235894,0.0007777842,0.00008886051,0.00007009014,0.0000803915,0.02708509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04492526,"threshold_uncertainty_score":0.9999137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009457176885649381,"score_gpt":0.2263559045282016,"score_spread":0.2168987276425522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}