{"id":"W2943567636","doi":"10.3747/co.26.4731","title":"A Canadian Guideline on the Use of Next-Generation Sequencing in Oncology","year":2019,"lang":"en","type":"article","venue":"Current Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Hospital for Sick Children; University of Toronto; Health Sciences Centre; CancerCare Manitoba; University of Alberta Hospital; Ottawa Hospital; University Health Network; Princess Margaret Cancer Centre; Sunnybrook Health Science Centre; Alberta Hospital Edmonton; Impact; Fluidigm (Canada)","funders":"Foundation Medicine; F. Hoffmann-La Roche; AstraZeneca; Pfizer","keywords":"Medicine; DECIPHER; Guideline; DNA sequencing; Genomics; Medical physics; Clinical trial; Clinical Oncology; Genomic sequencing; Computational biology; Bioinformatics; Cancer; Internal medicine; Pathology; Genome; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000255944,0.00009608165,0.000163693,0.00008289445,0.00002763962,0.00001078654,0.000138082,0.0001535289,0.0000766111],"category_scores_gemma":[0.0002901483,0.00007933102,0.00004724371,0.00008185393,0.00004031684,0.000003067674,0.00005286698,0.000133036,0.00002191957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006720112,"about_ca_system_score_gemma":0.001769679,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01118741,"about_ca_topic_score_gemma":0.2086943,"domain_scores_codex":[0.999105,0.0001039314,0.0002988694,0.0002225499,0.00005500457,0.0002146699],"domain_scores_gemma":[0.999342,0.0001001834,0.0001081726,0.0002765592,0.0001016868,0.00007139563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001920721,0.0002489671,0.02152115,0.00002638207,0.00005239683,0.0000158236,0.0004245682,0.01901312,0.685931,0.005160008,0.133531,0.1338835],"study_design_scores_gemma":[0.0004602592,0.0007451072,0.0003651723,0.00001188249,0.00000811448,0.000005929755,0.00008042435,0.005482255,0.01036379,0.00004639083,0.9823283,0.0001023952],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950931,0.0005384713,0.00009225254,0.001713971,0.00115375,0.0003074184,0.0000400114,0.000001953409,0.001059066],"genre_scores_gemma":[0.9965796,0.0006376581,0.0003093288,0.001831566,0.0003224616,0.00002723744,0.0002011907,0.00001174198,0.00007920828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8487973,"threshold_uncertainty_score":0.9953972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2153557568511918,"score_gpt":0.3647937102831273,"score_spread":0.1494379534319355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}