{"id":"W2943628495","doi":"10.1124/mol.118.115311","title":"Impact of Phosphodiesterase 4 Inhibition on the Operational Efficacy, Response Maxima, and Kinetics of Indacaterol-Induced Gene Expression Changes in BEAS-2B Airway Epithelial Cells: A Global Transcriptomic Analysis","year":2019,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Alberta Innovates; Gilead Sciences","keywords":"Indacaterol; Transcriptome; Phosphodiesterase; Gene expression; Kinetics; Maxima; Chemistry; Pharmacology; Cell biology; Gene; Molecular biology; Biology; Immunology; Biochemistry; Enzyme; Asthma; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001830371,0.0002786538,0.0005009095,0.0001909755,0.0001598991,0.0003989618,0.0001602548,0.0002544789,0.001313196],"category_scores_gemma":[0.0001959189,0.0001561225,0.0003703204,0.0002991642,0.0002447204,0.0002533607,0.0001582325,0.0006195558,0.0003054779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003020568,"about_ca_system_score_gemma":0.0002557169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009887211,"about_ca_topic_score_gemma":0.001180599,"domain_scores_codex":[0.9997937,0.0000212768,0.00001639297,0.00005355451,0.00006143498,0.00005366698],"domain_scores_gemma":[0.9998844,0.0000356468,0.00002456198,0.00001508337,0.00002240717,0.0000178926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002085584,0.00001863669,0.0001983889,0.00001353764,0.000003246838,0.000007485349,0.000006483184,0.00005528129,0.9990267,0.00001466325,0.00001228519,0.0004349496],"study_design_scores_gemma":[0.00001035443,0.0002980713,0.01489113,0.000002517211,0.0000181045,0.00002548473,0.00005983737,0.001090807,0.9830101,0.00002410468,0.0005625826,0.000007084079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945409,0.0007598262,0.001682436,0.00009794009,0.00003842012,0.00002941124,0.001894625,0.00005890469,0.0008975921],"genre_scores_gemma":[0.993372,0.0005384884,0.001774979,0.00007349953,0.000012863,0.00009158267,0.00177858,0.00002627624,0.002331805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001313196,"threshold_uncertainty_score":0.004393101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009178042996319103,"score_gpt":0.2743029873175831,"score_spread":0.265124944321264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}