{"id":"W2943665347","doi":"10.1038/s41586-019-1166-7","title":"Voltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamics","year":2019,"lang":"en","type":"article","venue":"Nature","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":342,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institute on Drug Abuse; National Institute of Biomedical Imaging and Bioengineering; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Howard Hughes Medical Institute","keywords":"Optogenetics; Neuroscience; Hippocampal formation; Context (archaeology); Premovement neuronal activity; Excitatory postsynaptic potential; Subthreshold conduction; Hippocampus; Slice preparation; Voltage-sensitive dye; Neuron; Inhibitory postsynaptic potential; Biology; Physics; Biophysics; Electrophysiology; Chemistry; Voltage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001052584,0.0002217525,0.0001924015,0.0002303751,0.0001974458,0.0006214952,0.0006339632,0.0004810443,0.001278373],"category_scores_gemma":[0.0004137003,0.0002669285,0.000278354,0.0002214398,0.0006318649,0.0006120151,0.0004647674,0.001027122,0.00022883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005385777,"about_ca_system_score_gemma":0.0002709357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001602978,"about_ca_topic_score_gemma":0.003733688,"domain_scores_codex":[0.9998744,0.000008245195,0.000006709391,0.00003454198,0.00003642557,0.00003974392],"domain_scores_gemma":[0.9997658,0.00005075871,0.00007736841,0.00003207986,0.00001869552,0.00005527821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004791157,0.00001075483,0.0003241854,0.000008136755,0.000002942405,0.00002216208,0.00001500881,0.00006254826,0.9974067,0.00022684,0.00003746211,0.001835338],"study_design_scores_gemma":[0.00002231999,0.0001173341,0.05525805,0.00001123403,0.00001871629,0.0003388044,0.0001111761,0.005530784,0.9367201,0.001058097,0.0007960563,0.00001719731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789083,0.0006607936,0.01707097,0.0004166444,0.00007198253,0.00001632061,0.0003293,0.0001506089,0.002375067],"genre_scores_gemma":[0.9919848,0.0003499964,0.005141796,0.000128371,0.00001617921,0.00002194852,0.0001230356,0.0001075594,0.002126405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001602978,"threshold_uncertainty_score":0.004276574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0130318127543287,"score_gpt":0.2986878017815742,"score_spread":0.2856559890272455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}