{"id":"W2943690701","doi":"10.3390/pharmaceutics11050199","title":"DPYD and Fluorouracil-Based Chemotherapy: Mini Review and Case Report","year":2019,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Fluorouracil; DPYD; Dihydropyrimidine dehydrogenase; Medicine; Dosing; Chemotherapy; Adverse effect; Pharmacokinetics; Precision medicine; Pharmacogenetics; Therapeutic drug monitoring; Pharmacology; Drug; Oncology; Internal medicine; Intensive care medicine; Thymidylate synthase; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002416145,0.0004387062,0.00217067,0.00006924175,0.00007760202,0.00001885642,0.00003989185,0.0001199536,0.0001235092],"category_scores_gemma":[0.00005668061,0.0003021364,0.0002270212,0.0001510462,0.00008472495,0.00002556024,0.00006338403,0.0003032123,0.00001393086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00012482,"about_ca_system_score_gemma":0.0002514065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001523896,"about_ca_topic_score_gemma":0.000003674797,"domain_scores_codex":[0.9985891,0.00005478531,0.0005037131,0.0004603874,0.0001609575,0.0002310471],"domain_scores_gemma":[0.9989676,0.0001420837,0.0002908005,0.0003386869,0.00008160686,0.0001792373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001737617,0.00005834851,0.00004964534,0.1310932,0.0006402032,0.01414274,0.00002583486,4.270448e-9,1.014981e-7,0.000001005656,0.002109697,0.8518618],"study_design_scores_gemma":[0.000886028,0.000132375,0.0000040734,0.01482684,0.01558521,0.05767432,0.000006510144,0.000006741647,0.000002692543,7.952846e-7,0.9106321,0.0002422574],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003432922,0.9954412,0.000001357696,0.0007858021,0.0001592741,0.002173706,0.00007068681,0.00003956637,0.001294054],"genre_scores_gemma":[0.00002431526,0.995434,0.000185509,0.002140303,0.000114121,0.0001434517,0.00007533246,0.000056475,0.001826489],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9085225,"threshold_uncertainty_score":0.9999431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1680817600237587,"score_gpt":0.4698942140530452,"score_spread":0.3018124540292865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}