{"id":"W2943690701","doi":"10.3390/pharmaceutics11050199","title":"DPYD and Fluorouracil-Based Chemotherapy: Mini Review and Case Report","year":2019,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Fluorouracil; DPYD; Dihydropyrimidine dehydrogenase; Medicine; Dosing; Chemotherapy; Adverse effect; Pharmacokinetics; Precision medicine; Pharmacogenetics; Therapeutic drug monitoring; Pharmacology; Drug; Oncology; Internal medicine; Intensive care medicine; Thymidylate synthase; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000336586,0.0009426304,0.001052966,0.004953974,0.0004653699,0.001018282,0.0008814932,0.00162135,0.00493762],"category_scores_gemma":[0.001376169,0.0003307929,0.0008258133,0.003747658,0.0006132258,0.001897241,0.0007457123,0.001445661,0.001197153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006468823,"about_ca_system_score_gemma":0.001452967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001349432,"about_ca_topic_score_gemma":0.00291595,"domain_scores_codex":[0.9997404,0.00004485619,0.00007904079,0.000045609,0.00006546635,0.00002469938],"domain_scores_gemma":[0.9992478,0.0004479975,0.0001721689,0.00001772058,0.00006770074,0.00004658523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"case_report","study_design_scores_codex":[0.000106794,0.0001359704,0.00232551,0.06147684,0.0003464873,0.03251847,0.0005164021,0.0005954047,0.001853181,0.005024861,0.07570037,0.8193998],"study_design_scores_gemma":[0.00002030684,0.0001091824,0.004782988,0.02592357,0.0005850776,0.2253892,0.000458438,0.0002096989,0.0005340321,0.002803904,0.7391192,0.00006430574],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004049605,0.9976438,0.0001070252,0.0004693019,0.0002829576,0.000007597018,0.00002448452,0.000006507786,0.001053344],"genre_scores_gemma":[0.003094341,0.9947666,0.0002637364,0.0006204354,0.0007719165,0.000009699695,0.00005552747,0.000002412569,0.0004153423],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004953974,"threshold_uncertainty_score":0.016518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1680817600237587,"score_gpt":0.4698942140530452,"score_spread":0.3018124540292865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}