{"id":"W2943700061","doi":"10.3791/59531","title":"Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8<sup>+</sup> T Cell Responses","year":2019,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; American Association of Immunologists","keywords":"Immunodominance; CTL*; Epitope; Biology; Cytotoxic T cell; Priming (agriculture); CD8; Antigen; Immunology; T cell; In vivo; Immune system; Virology; Cell biology; In vitro; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002607818,0.0005613316,0.001383509,0.001183701,0.0001918368,0.00008324898,0.0009614978,0.0002804274,0.001804446],"category_scores_gemma":[0.0002112086,0.0005166156,0.0003136774,0.0007146804,0.0001168043,0.0005328321,0.0002713973,0.0008349943,0.0005183016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005097815,"about_ca_system_score_gemma":0.0002114046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007643353,"about_ca_topic_score_gemma":0.000006002278,"domain_scores_codex":[0.9940428,0.002248095,0.001957838,0.0005505575,0.0002867139,0.000913968],"domain_scores_gemma":[0.9976767,0.0005596446,0.0008151678,0.000702425,0.000179335,0.0000667421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03061399,0.003251692,0.009990569,0.00001593389,0.0002109446,0.0002225504,0.01150995,0.00007783386,0.9430997,0.00003020269,0.000567811,0.0004088657],"study_design_scores_gemma":[0.0192729,0.003235183,0.02414613,0.0003693376,0.00001921346,0.0001847845,0.005243285,0.000006481105,0.9224713,0.00001283639,0.02449046,0.0005480317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774999,0.01959565,0.00004948699,0.00004833768,0.001146429,0.00117043,0.00001308199,0.00002847136,0.0004482348],"genre_scores_gemma":[0.9953908,0.0006736925,0.0003700159,0.0001809634,0.00004917596,0.00006910435,0.000002673007,0.00007770569,0.003185911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02392265,"threshold_uncertainty_score":0.9997286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02397898235854561,"score_gpt":0.3473448909809567,"score_spread":0.323365908622411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}