{"id":"W2943704702","doi":"10.1172/jci.insight.127232","title":"Intracellular cholesterol biosynthesis in enchondroma and chondrosarcoma","year":2019,"lang":"en","type":"article","venue":"JCI Insight","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Hospital for Sick Children","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health","keywords":"Enchondroma; Chondrosarcoma; Intracellular; IDH1; Isocitrate dehydrogenase; Cancer research; Cholesterol; Chemistry; Biochemistry; Mutant; Cell biology; Biology; Gene; Pathology; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007500814,0.0002456181,0.0002535293,0.0003912562,0.0001956844,0.0002901722,0.00009489842,0.0002537821,0.000500117],"category_scores_gemma":[0.00008886008,0.0001422897,0.0001996358,0.0002336345,0.0001888232,0.0001336751,0.0001656427,0.0002514302,0.0002349435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003653977,"about_ca_system_score_gemma":0.0003602264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002262269,"about_ca_topic_score_gemma":0.004798907,"domain_scores_codex":[0.9998733,0.000007763184,0.000009042474,0.00003415439,0.0000543339,0.00002141432],"domain_scores_gemma":[0.999922,0.000009087958,0.00002612393,0.000007278704,0.00001617131,0.00001925134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004851984,0.000002602243,0.0003756285,0.0000288499,0.000002109345,0.0000527638,0.0000101107,0.00002345181,0.9987645,0.0000376986,0.00001684982,0.0006368291],"study_design_scores_gemma":[0.00001567621,0.0001130334,0.05223789,0.00002192411,0.00004298992,0.0008292955,0.0001271144,0.0009064802,0.9395722,0.0001453615,0.005975856,0.00001208927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862897,0.006417413,0.002861927,0.0001151522,0.00003795597,0.00002929281,0.001898343,0.00009799879,0.002252102],"genre_scores_gemma":[0.9851526,0.003058874,0.004036071,0.0001050634,0.00001123308,0.00003951095,0.002386357,0.0000386887,0.005171553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002262269,"threshold_uncertainty_score":0.004498243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00525007561790277,"score_gpt":0.2215051367604327,"score_spread":0.2162550611425299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}