{"id":"W2943704702","doi":"10.1172/jci.insight.127232","title":"Intracellular cholesterol biosynthesis in enchondroma and chondrosarcoma","year":2019,"lang":"en","type":"article","venue":"JCI Insight","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Hospital for Sick Children","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health","keywords":"Enchondroma; Chondrosarcoma; Intracellular; IDH1; Isocitrate dehydrogenase; Cancer research; Cholesterol; Chemistry; Biochemistry; Mutant; Cell biology; Biology; Gene; Pathology; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001486131,0.0001809743,0.0001859561,0.0001526361,0.00003437468,0.00004429798,0.0002056563,0.0002655949,0.0001427941],"category_scores_gemma":[0.00005190281,0.0001794959,0.00005901269,0.0001822084,0.00005755317,0.000008232545,0.0001921093,0.0002135556,0.000112831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003426397,"about_ca_system_score_gemma":0.00006464477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005059794,"about_ca_topic_score_gemma":0.0000901849,"domain_scores_codex":[0.9986469,0.0000856063,0.0002041972,0.0005170699,0.0001992662,0.0003469451],"domain_scores_gemma":[0.9992992,0.00001418907,0.00004610639,0.0004913677,0.00003819691,0.0001109764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005365844,0.00006079951,0.0008385959,0.00002729336,0.00002363721,0.00002214594,0.00007148826,0.0000195918,0.9950122,0.0001107704,0.0001986016,0.003561196],"study_design_scores_gemma":[0.0009457985,0.0002991945,0.002447435,0.00003941352,0.00000662951,0.00004851346,0.00003461922,0.0002885296,0.9194164,0.00006227641,0.0761717,0.0002395392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942784,0.001715025,0.0005390008,0.0002256262,0.0001823142,0.0003950596,0.000007895589,0.00001360709,0.00264311],"genre_scores_gemma":[0.9973285,0.0004265294,0.0002901889,0.0002439865,0.00007905201,0.00003162304,0.0000344359,0.00003928249,0.001526368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0759731,"threshold_uncertainty_score":0.7319629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00525007561790277,"score_gpt":0.2215051367604327,"score_spread":0.2162550611425299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}