{"id":"W2943711511","doi":"10.1016/j.lungcan.2019.04.027","title":"Selumetinib in patients receiving standard pemetrexed and platinum-based chemotherapy for advanced or metastatic KRAS wildtype or unknown non-squamous non-small cell lung cancer: A randomized, multicenter, phase II study. Canadian Cancer Trials Group (CCTG) IND.219","year":2019,"lang":"en","type":"article","venue":"Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Abbotsford Veterinary Clinic; Juravinski Cancer Centre; Lakeridge Health; BC Cancer Agency; Princess Margaret Cancer Centre; Ottawa Hospital; Hôpital Notre-Dame; Hamilton Health Sciences; University of Toronto","funders":"AstraZeneca","keywords":"Medicine; Pemetrexed; Selumetinib; Chemotherapy; Internal medicine; Hazard ratio; Tolerability; Carboplatin; Oncology; Lung cancer; Surgery; Adverse effect; Gastroenterology; KRAS; Cancer; Cisplatin; Confidence interval; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001223775,0.0007216648,0.002578809,0.0005819317,0.0003174579,0.00009113301,0.0002079045,0.0001665497,0.001142911],"category_scores_gemma":[0.0004447339,0.0005100422,0.0002921213,0.000747404,0.00007865753,0.0002459248,0.00004127877,0.0003338735,0.000001705465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002830872,"about_ca_system_score_gemma":0.003700644,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.09340712,"about_ca_topic_score_gemma":0.4388573,"domain_scores_codex":[0.9957635,0.0003248321,0.001352071,0.00105029,0.0005317312,0.0009775839],"domain_scores_gemma":[0.9964609,0.001246454,0.0007962549,0.0005018186,0.000459561,0.0005349869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5156343,0.003989644,0.3241853,0.002942185,0.003963154,0.00007006091,0.0140373,0.001544312,0.0008027546,0.000002874989,0.003108922,0.1297192],"study_design_scores_gemma":[0.9478691,0.006537994,0.009054765,0.002164795,0.005447234,0.000001182227,0.001091693,0.02115285,0.001310883,0.000003332063,0.004448395,0.0009177332],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9667688,0.003600554,0.000486848,0.0006242168,0.00140558,0.02532449,0.001586795,0.00005910535,0.0001436278],"genre_scores_gemma":[0.9815077,0.001106414,0.003271303,0.001272556,0.0001953689,0.009638309,0.0002657203,0.0001851255,0.002557489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4322348,"threshold_uncertainty_score":0.9997702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01689900624200209,"score_gpt":0.3665936275924145,"score_spread":0.3496946213504124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}