{"id":"W2943711511","doi":"10.1016/j.lungcan.2019.04.027","title":"Selumetinib in patients receiving standard pemetrexed and platinum-based chemotherapy for advanced or metastatic KRAS wildtype or unknown non-squamous non-small cell lung cancer: A randomized, multicenter, phase II study. Canadian Cancer Trials Group (CCTG) IND.219","year":2019,"lang":"en","type":"article","venue":"Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Abbotsford Veterinary Clinic; Juravinski Cancer Centre; Lakeridge Health; BC Cancer Agency; Princess Margaret Cancer Centre; Ottawa Hospital; Hôpital Notre-Dame; Hamilton Health Sciences; University of Toronto","funders":"AstraZeneca","keywords":"Medicine; Pemetrexed; Selumetinib; Chemotherapy; Internal medicine; Hazard ratio; Tolerability; Carboplatin; Oncology; Lung cancer; Surgery; Adverse effect; Gastroenterology; KRAS; Cancer; Cisplatin; Confidence interval; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009101368,0.0008360553,0.001547199,0.000259823,0.0002441257,0.0006451354,0.0005528381,0.000821254,0.003494137],"category_scores_gemma":[0.0009565317,0.0003717728,0.001317886,0.000343104,0.0005277638,0.00080365,0.0003157269,0.001682238,0.0004177359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007551493,"about_ca_system_score_gemma":0.0009615843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001695347,"about_ca_topic_score_gemma":0.005263231,"domain_scores_codex":[0.9996536,0.000182914,0.00002028364,0.00004654338,0.0000381873,0.00005862508],"domain_scores_gemma":[0.9996346,0.00008917868,0.00008201279,0.00001988419,0.00002270802,0.0001515834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9271418,0.006359849,0.005228501,0.0005134953,0.00232747,0.0000629879,0.00005736065,0.0007163026,0.003805998,0.0001484204,0.003339062,0.0502986],"study_design_scores_gemma":[0.8586406,0.1148364,0.02011298,0.00007873326,0.001753902,0.00008284061,0.00006561261,0.0007669989,0.0009359905,0.0001746043,0.002525233,0.00002616389],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871184,0.007312824,0.0001687486,0.0007851794,0.0003157829,0.0007094259,0.001231859,0.00004900024,0.002308744],"genre_scores_gemma":[0.9886237,0.004561366,0.000508204,0.00106293,0.000269331,0.0009421244,0.001911154,0.00001129054,0.002109804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003494137,"threshold_uncertainty_score":0.01168907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01689900624200209,"score_gpt":0.3665936275924145,"score_spread":0.3496946213504124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}