{"id":"W2943834620","doi":"10.1158/1538-7445.sabcs18-p1-05-05","title":"Abstract P1-05-05: eEF1A2 facilitates PTEN-GSK3β mediated Aurora-A protein degradation during S-G2 phase inactivated in PTEN-deficient breast cancer","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"PTEN; Cancer research; Protein kinase B; Ubiquitin ligase; Skp1; SKP2; Phosphorylation; Biology; F-box protein; Mitosis; Cell cycle; Kinase; Protein degradation; Ubiquitin; Cell biology; Chemistry; Signal transduction; PI3K/AKT/mTOR pathway; Cell; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001177566,0.0002409089,0.0002410348,0.0001642374,0.0001448841,0.0002429177,0.0002075423,0.0001933538,0.002409843],"category_scores_gemma":[0.00008989887,0.0001207043,0.0002699405,0.0001543609,0.0001430642,0.000127808,0.0001796819,0.0004807772,0.0007753016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002372405,"about_ca_system_score_gemma":0.0001827257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006491242,"about_ca_topic_score_gemma":0.000630187,"domain_scores_codex":[0.999885,0.00001518353,0.00001227323,0.00002667162,0.0000260482,0.00003477002],"domain_scores_gemma":[0.9999357,0.000009248417,0.00001549835,0.000007461123,0.000005131697,0.00002696456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005253497,0.0001103235,0.0002926903,0.00004822544,0.00001154828,0.0001077007,0.00001401186,0.00007326593,0.9970186,0.00008432857,0.0002517579,0.0014623],"study_design_scores_gemma":[0.00007722206,0.0007588008,0.007251339,0.000007115803,0.00001926988,0.0004690683,0.0000306392,0.001161888,0.9866328,0.00003727099,0.00355024,0.000004274222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941855,0.001183033,0.001211731,0.0001582151,0.00005134493,0.0000315057,0.001208657,0.0001472878,0.001822807],"genre_scores_gemma":[0.9935786,0.0003883108,0.0008629042,0.00006346136,0.000008907275,0.0000557356,0.001579531,0.00002352334,0.00343909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002409843,"threshold_uncertainty_score":0.008061707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02787972265049142,"score_gpt":0.3469134506743491,"score_spread":0.3190337280238577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}