{"id":"W2943839899","doi":"10.3390/md17050286","title":"TAT-Modified ω-Conotoxin MVIIA for Crossing the Blood-Brain Barrier","year":2019,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health; University of British Columbia","funders":"","keywords":"Nasal administration; Pharmacology; Chemistry; Medicine; Blood–brain barrier; Opioid; Central nervous system; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001070587,0.0002396857,0.0001568671,0.00009863049,0.0001093577,0.000199021,0.0001763988,0.0002929379,0.0005634771],"category_scores_gemma":[0.00009411995,0.00006006781,0.0001362833,0.0001214931,0.0001622917,0.00023544,0.0001663026,0.0004030415,0.0002327212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002397115,"about_ca_system_score_gemma":0.0001412374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000433969,"about_ca_topic_score_gemma":0.0003954591,"domain_scores_codex":[0.9999141,0.0000188546,0.00000759214,0.00002158336,0.00002011798,0.00001777776],"domain_scores_gemma":[0.9999654,0.000004248825,0.00001260446,0.000004738894,0.000005986777,0.000006985021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001548832,0.000008604665,0.00004481084,0.00001949365,0.000002016429,0.00002600218,0.000006236834,0.00007176078,0.9988402,0.0001866395,0.00002023811,0.0007585546],"study_design_scores_gemma":[0.000003920854,0.0001246653,0.0003953392,0.000003998739,0.000007194443,0.0001129845,0.00001000882,0.001340829,0.9954609,0.0000396169,0.002497497,0.000002935876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711804,0.00334745,0.0234623,0.0001734102,0.00007666252,0.00004376308,0.0001307646,0.00009134885,0.001493827],"genre_scores_gemma":[0.9875988,0.001378819,0.008325461,0.00007123969,0.000007421923,0.00002063225,0.0001853051,0.00001485789,0.002397453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005634771,"threshold_uncertainty_score":0.001884997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005928948164367856,"score_gpt":0.2336024119408688,"score_spread":0.2276734637765009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}