{"id":"W2943839899","doi":"10.3390/md17050286","title":"TAT-Modified ω-Conotoxin MVIIA for Crossing the Blood-Brain Barrier","year":2019,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health; University of British Columbia","funders":"","keywords":"Nasal administration; Pharmacology; Chemistry; Medicine; Blood–brain barrier; Opioid; Central nervous system; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004013689,0.0001443759,0.0001349185,0.00001954835,0.0001879798,0.0001198373,0.0002244597,0.0001074358,0.0003193768],"category_scores_gemma":[0.00006561381,0.0001067306,0.0001387011,0.00004436451,0.00005004683,0.000003661146,0.0001756328,0.00007970162,0.00001958528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006390511,"about_ca_system_score_gemma":0.00006009551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003571515,"about_ca_topic_score_gemma":0.00001112398,"domain_scores_codex":[0.9991173,0.00003758936,0.0001728664,0.0003094608,0.00009128512,0.0002715686],"domain_scores_gemma":[0.9994311,0.00004367753,0.00006650008,0.0003579142,0.00004693182,0.00005385952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007189015,0.00001989775,0.0004556092,0.00001933051,0.00005037628,4.658754e-7,0.0001573449,0.00008052383,0.9887754,0.001523113,0.001167522,0.007678531],"study_design_scores_gemma":[0.001106474,0.0001593629,0.0001669395,0.000007635654,0.00002166704,0.000004582389,0.0001399843,0.0005900375,0.7865224,0.001029297,0.2100414,0.0002101415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928537,0.0001269367,0.002023952,0.0004222417,0.0003291085,0.0004352396,0.00001617508,0.00001459586,0.003778055],"genre_scores_gemma":[0.977614,0.000008609391,0.0009953646,0.001179865,0.0003268524,0.00005766187,0.0001123109,0.00003367012,0.0196716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2088739,"threshold_uncertainty_score":0.4352348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005928948164367856,"score_gpt":0.2336024119408688,"score_spread":0.2276734637765009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}