{"id":"W2943864790","doi":"10.1016/s1470-2045(19)30178-0","title":"Trebananib or placebo plus carboplatin and paclitaxel as first-line treatment for advanced ovarian cancer (TRINOVA-3/ENGOT-ov2/GOG-3001): a randomised, double-blind, phase 3 trial","year":2019,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Cilag; Genentech; F. Hoffmann-La Roche; Roche; Merck; Amgen","keywords":"Medicine; Clinical endpoint; Ovarian cancer; Carboplatin; Population; Progression-free survival; Internal medicine; Placebo; Oncology; Phases of clinical research; Clinical trial; Gynecology; Cancer; Chemotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001547844,0.002086475,0.004177494,0.0005882981,0.0004329452,0.00119658,0.001084429,0.002276028,0.01095668],"category_scores_gemma":[0.00138998,0.0008805643,0.002230582,0.0005368801,0.001352516,0.00142099,0.0004382927,0.004158676,0.001902737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007000647,"about_ca_system_score_gemma":0.0009185396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001286097,"about_ca_topic_score_gemma":0.002587963,"domain_scores_codex":[0.9995232,0.0002277149,0.00002669231,0.00009394441,0.00002926463,0.00009917768],"domain_scores_gemma":[0.9993795,0.0001875234,0.0001076029,0.00005303787,0.00003242486,0.000239885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9846995,0.002034844,0.0001109185,0.0005293008,0.0005375861,0.00001856468,0.00002398339,0.0002012418,0.001511263,0.00009507559,0.0007114279,0.009526301],"study_design_scores_gemma":[0.9744145,0.02414621,0.0003697206,0.00002097482,0.0001893435,0.00001692303,0.00001103815,0.000192654,0.0001623303,0.0001114692,0.000355744,0.000009158083],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9649707,0.01345608,0.001583542,0.001974487,0.002460292,0.006429267,0.002900956,0.0006362028,0.005588486],"genre_scores_gemma":[0.967496,0.007529994,0.002101418,0.002138348,0.0008434879,0.005870429,0.002207903,0.0001133002,0.01169922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01095668,"threshold_uncertainty_score":0.03665376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08349518990222415,"score_gpt":0.400998555831424,"score_spread":0.3175033659291999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}