{"id":"W2943981373","doi":"10.1210/js.2019-sat-031","title":"SAT-031 Understanding Gβγ Isoform Interactome Profiles in Fibrotic Gene Regulation","year":2019,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Interactome; Heterotrimeric G protein; Gene isoform; HEK 293 cells; Cell biology; Biology; Transcription (linguistics); Transcription factor; Promoter; Cardiac fibrosis; Gene; Gene expression; Molecular biology; Signal transduction; Genetics; G protein; Fibrosis; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001660473,0.0002056637,0.0002371918,0.0008025722,0.0002174895,0.0006071488,0.0001990405,0.0003483788,0.00748886],"category_scores_gemma":[0.0001871953,0.0001388613,0.000337954,0.001034791,0.0001172358,0.0003201911,0.0002500802,0.0003299073,0.002196181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002273466,"about_ca_system_score_gemma":0.000205782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000804709,"about_ca_topic_score_gemma":0.001375499,"domain_scores_codex":[0.99992,0.000008556058,0.000004318181,0.00002413252,0.00002481276,0.00001815936],"domain_scores_gemma":[0.9999057,0.00002301957,0.00001910362,0.00001002407,0.00002518116,0.00001703626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003682981,0.00003255434,0.01670023,0.0002592899,0.00005224667,0.0001624791,0.00008998963,0.0004640335,0.947866,0.0009801607,0.002151321,0.03087363],"study_design_scores_gemma":[0.00005693204,0.0003938157,0.6569502,0.0001081416,0.0001968696,0.002444741,0.0005202087,0.02145743,0.2601658,0.004980719,0.05268779,0.00003741368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9416957,0.006640882,0.02245953,0.0009765408,0.00007316733,0.00005477617,0.01291683,0.0006022762,0.01458029],"genre_scores_gemma":[0.9283921,0.005483921,0.02390167,0.0006105187,0.0000881888,0.0001233075,0.02707515,0.0001899811,0.01413517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00748886,"threshold_uncertainty_score":0.02505267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0122165747908207,"score_gpt":0.2355492135381026,"score_spread":0.2233326387472819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}