{"id":"W2943981373","doi":"10.1210/js.2019-sat-031","title":"SAT-031 Understanding Gβγ Isoform Interactome Profiles in Fibrotic Gene Regulation","year":2019,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Interactome; Heterotrimeric G protein; Gene isoform; HEK 293 cells; Cell biology; Biology; Transcription (linguistics); Transcription factor; Promoter; Cardiac fibrosis; Gene; Gene expression; Molecular biology; Signal transduction; Genetics; G protein; Fibrosis; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000258967,0.00009189263,0.0001392353,0.0000232,0.00004544142,0.00002402613,0.0001839515,0.00005048985,0.0001091773],"category_scores_gemma":[0.00003233681,0.00006188034,0.0002815073,0.00008513589,0.00001854745,0.00001332402,0.00008392286,0.0001766548,0.000003143302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001053738,"about_ca_system_score_gemma":0.0000536308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003552115,"about_ca_topic_score_gemma":0.000002260156,"domain_scores_codex":[0.9992466,0.00003996234,0.0002828531,0.0001025326,0.0001670425,0.0001610282],"domain_scores_gemma":[0.9995031,0.00001590944,0.0002481865,0.0001498623,0.00005151435,0.00003141921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003960168,0.00002099944,0.006017633,0.00002176013,0.00005148127,9.334029e-7,0.0001761196,0.0008941879,0.9911073,0.0001435682,0.001410371,0.0001159927],"study_design_scores_gemma":[0.001246724,0.000287508,0.005819638,0.000147966,0.00002302106,0.0001507673,0.001508731,0.0009531174,0.9844602,0.002008481,0.003229247,0.0001646028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961402,0.0002405226,0.002374241,0.0004064325,0.0005323566,0.0001293995,0.000002122287,0.000002161268,0.0001725283],"genre_scores_gemma":[0.9972144,0.00008362677,0.001580993,0.0001382182,0.0002714182,0.000001019109,0.000005746941,0.00001294223,0.0006915745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006647156,"threshold_uncertainty_score":0.2523407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0122165747908207,"score_gpt":0.2355492135381026,"score_spread":0.2233326387472819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}