{"id":"W2944046200","doi":"10.1038/s41467-019-09775-w","title":"Association analyses identify 31 new risk loci for colorectal cancer susceptibility","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":272,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Alberta Cancer Foundation; University of Alberta; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"FP7 Health; National Cancer Institute; Instituto de Salud Carlos III; Medical Research Council; National Institutes of Health; University of Edinburgh; Hellenic Health Foundation; Xunta de Galicia; Directorate for Biological Sciences; Herzfelder'sche Familienstiftung; Institut Gustave-Roussy; Medizinische Universität Graz; Mutuelle Générale de l'Education Nationale; Deutsche Krebshilfe; NordForsk; Scottish Funding Council; Tenovus; World Cancer Research Fund; Age UK; Stavros Niarchos Foundation; Kuopion Yliopistollinen Sairaala; Sydäntutkimussäätiö; Opetus- ja Kulttuuriministeriö; Jane ja Aatos Erkon Säätiö; Institut National de la Santé et de la Recherche Médicale; Karl-Franzens-Universität Graz; Deutsche Forschungsgemeinschaft; European Commission; Associazione Italiana per la Ricerca sul Cancro; Netherlands eScience Center; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Bundesministerium für Bildung und Forschung; China Scholarship Council; Foundation for Cardiovascular Research; Academy of Finland; National Institute on Alcohol Abuse and Alcoholism; Centre for Cognitive Ageing and Cognitive Epidemiology; National Institute for Health and Care Research; Cancer Research Institute; National Cancer Research Institute; Royal Marsden NHS Foundation Trust; Scottish Government; National Heart, Lung, and Blood Institute; Biotechnology and Biological Sciences Research Council; Cancer Research UK; Wellcome Trust; Cancer Research Wales; University of Cambridge; Centre International de Recherche sur le Cancer; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; National Institute for Social Care and Health Research","keywords":"Colorectal cancer; Genome-wide association study; Genetics; Biology; Medicine; Cancer; Computational biology; Single-nucleotide polymorphism; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008406114,0.0003964675,0.0004159981,0.001146172,0.0003342945,0.0005349052,0.0003097893,0.0005823344,0.002794975],"category_scores_gemma":[0.003050425,0.000233209,0.0006786938,0.001424276,0.0004225844,0.0001599815,0.0004376804,0.000634937,0.0003996531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001513471,"about_ca_system_score_gemma":0.0002161513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001631072,"about_ca_topic_score_gemma":0.002800727,"domain_scores_codex":[0.999209,0.000221411,0.00007248498,0.0002374738,0.0001698393,0.00008978547],"domain_scores_gemma":[0.9976869,0.001253393,0.0005463237,0.0001717605,0.0001393221,0.0002023031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001199842,0.00007931155,0.9453126,0.00008614361,0.0008318039,0.001189247,0.0002130945,0.0006765035,0.02668689,0.0003826428,0.0004318588,0.0229101],"study_design_scores_gemma":[0.00005787643,0.0002001802,0.9913082,0.00001541529,0.0003783629,0.001804133,0.00007509278,0.001086154,0.002548335,0.0004666436,0.002041853,0.00001794211],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935541,0.001703532,0.002914751,0.0001634264,0.00002245062,0.00001506364,0.0004879531,0.00004948928,0.00108913],"genre_scores_gemma":[0.9963696,0.0004055829,0.002199573,0.00005311406,0.00002736094,0.000009837396,0.0004320048,0.00001261553,0.0004902806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002794975,"threshold_uncertainty_score":0.009350121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04872453073744815,"score_gpt":0.4170129404580242,"score_spread":0.368288409720576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}