{"id":"W2944046200","doi":"10.1038/s41467-019-09775-w","title":"Association analyses identify 31 new risk loci for colorectal cancer susceptibility","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":272,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Alberta Cancer Foundation; University of Alberta; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"FP7 Health; National Cancer Institute; Instituto de Salud Carlos III; Medical Research Council; National Institutes of Health; University of Edinburgh; Hellenic Health Foundation; Xunta de Galicia; Directorate for Biological Sciences; Herzfelder'sche Familienstiftung; Institut Gustave-Roussy; Medizinische Universität Graz; Mutuelle Générale de l'Education Nationale; Deutsche Krebshilfe; NordForsk; Scottish Funding Council; Tenovus; World Cancer Research Fund; Age UK; Stavros Niarchos Foundation; Kuopion Yliopistollinen Sairaala; Sydäntutkimussäätiö; Opetus- ja Kulttuuriministeriö; Jane ja Aatos Erkon Säätiö; Institut National de la Santé et de la Recherche Médicale; Karl-Franzens-Universität Graz; Deutsche Forschungsgemeinschaft; European Commission; Associazione Italiana per la Ricerca sul Cancro; Netherlands eScience Center; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Bundesministerium für Bildung und Forschung; China Scholarship Council; Foundation for Cardiovascular Research; Academy of Finland; National Institute on Alcohol Abuse and Alcoholism; Centre for Cognitive Ageing and Cognitive Epidemiology; National Institute for Health and Care Research; Cancer Research Institute; National Cancer Research Institute; Royal Marsden NHS Foundation Trust; Scottish Government; National Heart, Lung, and Blood Institute; Biotechnology and Biological Sciences Research Council; Cancer Research UK; Wellcome Trust; Cancer Research Wales; University of Cambridge; Centre International de Recherche sur le Cancer; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; National Institute for Social Care and Health Research","keywords":"Colorectal cancer; Genome-wide association study; Genetics; Biology; Medicine; Cancer; Computational biology; Single-nucleotide polymorphism; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000430663,0.000156317,0.0003196503,0.00009514215,0.0001841996,0.00003535357,0.0005351289,0.0004954268,0.0004159253],"category_scores_gemma":[0.001518503,0.0001452677,0.0002266251,0.0004302099,0.00005649375,0.00007787936,0.0001769015,0.00104605,0.00006734182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001019994,"about_ca_system_score_gemma":0.0005542333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006967865,"about_ca_topic_score_gemma":0.008206913,"domain_scores_codex":[0.9987011,0.0001219298,0.0003018359,0.0003012146,0.0003256406,0.0002482886],"domain_scores_gemma":[0.9967559,0.0008685589,0.0002969916,0.001366833,0.0005881856,0.0001235222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001379465,0.0001215989,0.874867,0.00003389445,0.0003570165,7.965593e-8,0.0002483391,0.00004408414,0.02781492,0.00005838579,0.09396527,0.002351468],"study_design_scores_gemma":[0.001462628,0.0002105256,0.8933694,0.0000411141,0.0006755534,0.00000160874,0.0001289111,0.001021016,0.01453053,0.0005238854,0.08782849,0.0002063243],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808959,0.007826886,0.00009848941,0.00586898,0.0007249552,0.001489258,0.0002001247,0.0001018749,0.002793517],"genre_scores_gemma":[0.9864919,0.00117379,0.007136071,0.0004471874,0.0001766106,0.000156944,0.0002815411,0.00002661631,0.004109302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01850242,"threshold_uncertainty_score":0.5923844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04872453073744815,"score_gpt":0.4170129404580242,"score_spread":0.368288409720576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}