{"id":"W2944090840","doi":"10.1016/j.ejpb.2019.05.004","title":"Niclosamide repositioning for treating cancer: Challenges and nano-based drug delivery opportunities","year":2019,"lang":"en","type":"review","venue":"European Journal of Pharmaceutics and Biopharmaceutics","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":105,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; U.S. Department of Energy","keywords":"Niclosamide; Medicine; Drug; Biopharmaceutical; Drug delivery; Clinical trial; Drug repositioning; Pharmacology; Prostate cancer; Cancer; Intensive care medicine; Nanotechnology; Biotechnology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005815635,0.001041027,0.002468486,0.000621841,0.0005550379,0.0001586229,0.0006567485,0.0003839729,0.00006058325],"category_scores_gemma":[0.00009959783,0.0009070344,0.0008060779,0.0001956592,0.0004682779,0.0003103013,0.0002770856,0.002017506,0.00001600858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002099433,"about_ca_system_score_gemma":0.0007033547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004043391,"about_ca_topic_score_gemma":0.000002735042,"domain_scores_codex":[0.9924185,0.003075279,0.002461882,0.000702907,0.000429565,0.000911927],"domain_scores_gemma":[0.993233,0.002074193,0.002881965,0.0003101229,0.0006013109,0.0008993759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003661896,0.0002120575,0.00001776059,0.03047633,0.001630642,0.0004479545,0.0006895908,0.00007836024,0.0004135186,0.0001957682,0.001276045,0.9641958],"study_design_scores_gemma":[0.003510797,0.0003066103,0.000002106373,0.0070857,0.008360224,0.0008132304,0.0005828944,0.002802325,0.0008226583,0.00001887185,0.9747857,0.0009088424],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001926684,0.9902285,0.00003957603,0.0006345004,0.003572855,0.001287056,0.001004525,0.00006875712,0.001237573],"genre_scores_gemma":[0.004847409,0.9909033,0.0005211323,0.001157289,0.001613911,0.0000334801,0.00006552584,0.0002098185,0.0006481771],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9735097,"threshold_uncertainty_score":0.999338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4338339020698205,"score_gpt":0.4684047069654056,"score_spread":0.03457080489558512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}