{"id":"W2944179533","doi":"10.1158/1078-0432.ccr-19-0191","title":"<i>NRG1</i> Gene Fusions Are Recurrent, Clinically Actionable Gene Rearrangements in <i>KRAS</i> Wild-Type Pancreatic Ductal Adenocarcinoma","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Lunenfeld-Tanenbaum Research Institute; Vancouver General Hospital; Ontario Institute for Cancer Research; Simon Fraser University; Princess Margaret Cancer Centre; BC Cancer Agency; Pancreas Centre (Canada); Canada's Michael Smith Genome Sciences Centre","funders":"BC Cancer Foundation; Genome British Columbia; Pfizer; Eli Lilly and Company","keywords":"KRAS; Afatinib; Adenocarcinoma; Pancreatic cancer; Cancer research; Medicine; Fusion gene; Oncology; ERBB3; Neuregulin 1; Cancer; Biology; Gene; Internal medicine; Erlotinib; Genetics; Epidermal growth factor receptor; Receptor; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00804536,0.0003311582,0.001570704,0.0004666616,0.0002658973,0.00005625564,0.0006362838,0.0006374682,0.004596157],"category_scores_gemma":[0.004124105,0.0002822662,0.0003182055,0.001684549,0.0007845571,0.0001745243,0.000587564,0.003258463,0.002344698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006742559,"about_ca_system_score_gemma":0.002682743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001043389,"about_ca_topic_score_gemma":0.0003281425,"domain_scores_codex":[0.9918854,0.001577507,0.001782521,0.001355951,0.001872403,0.001526254],"domain_scores_gemma":[0.9933218,0.002936495,0.0002766681,0.001352062,0.001195245,0.000917758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005466649,0.001379526,0.9628724,0.000212823,0.0002773205,0.0003735102,0.00009876001,0.000003809728,0.003659837,0.00003333973,0.02359593,0.002026059],"study_design_scores_gemma":[0.00766603,0.003418401,0.9691888,0.0006150643,0.0001862189,0.00006069661,0.0003493491,0.0004055253,0.0002329959,0.0003305624,0.01724097,0.0003053934],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977363,0.004572284,0.000007761128,0.00474766,0.001115515,0.002341612,0.00005367861,0.00006417902,0.009734282],"genre_scores_gemma":[0.9541734,0.02232382,0.001114939,0.001335849,0.001472857,0.0004165896,0.0001141466,0.00008780043,0.01896053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02318956,"threshold_uncertainty_score":0.9999629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2201857745108169,"score_gpt":0.5155043420277728,"score_spread":0.295318567516956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}