{"id":"W2944179533","doi":"10.1158/1078-0432.ccr-19-0191","title":"<i>NRG1</i> Gene Fusions Are Recurrent, Clinically Actionable Gene Rearrangements in <i>KRAS</i> Wild-Type Pancreatic Ductal Adenocarcinoma","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Lunenfeld-Tanenbaum Research Institute; Vancouver General Hospital; Ontario Institute for Cancer Research; Simon Fraser University; Princess Margaret Cancer Centre; BC Cancer Agency; Pancreas Centre (Canada); Canada's Michael Smith Genome Sciences Centre","funders":"BC Cancer Foundation; Genome British Columbia; Pfizer; Eli Lilly and Company","keywords":"KRAS; Afatinib; Adenocarcinoma; Pancreatic cancer; Cancer research; Medicine; Fusion gene; Oncology; ERBB3; Neuregulin 1; Cancer; Biology; Gene; Internal medicine; Erlotinib; Genetics; Epidermal growth factor receptor; Receptor; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003089307,0.0005878446,0.0009377412,0.0004766851,0.0008311439,0.001594599,0.001249149,0.006393123,0.002297706],"category_scores_gemma":[0.006116325,0.000347646,0.0005286938,0.0005779166,0.002903329,0.0007908816,0.0005342229,0.008610426,0.001767549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002083227,"about_ca_system_score_gemma":0.001214909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00341737,"about_ca_topic_score_gemma":0.007548027,"domain_scores_codex":[0.9983747,0.0005414856,0.0001380707,0.000428821,0.0003946822,0.0001222467],"domain_scores_gemma":[0.9944465,0.003992099,0.0003482032,0.0001764448,0.0008185207,0.0002181291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.001171224,0.00006819198,0.002958391,0.0005217922,0.0001065263,0.003246874,0.0002195781,0.00026334,0.01013129,0.002450888,0.9144096,0.06445234],"study_design_scores_gemma":[0.0006670788,0.000655599,0.02458193,0.0009341617,0.0004002799,0.006555846,0.0005792114,0.001106905,0.01620129,0.007221183,0.9409392,0.0001573851],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.02135244,0.05196126,0.001417589,0.8360417,0.070297,0.0001598282,0.0009788,0.0005635662,0.01722783],"genre_scores_gemma":[0.1328391,0.08094574,0.00132179,0.5636188,0.1922616,0.0002575594,0.0004275786,0.0002785628,0.02804928],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006393123,"threshold_uncertainty_score":0.01633805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2201857745108169,"score_gpt":0.5155043420277728,"score_spread":0.295318567516956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}