{"id":"W2944207417","doi":"10.1101/630970","title":"Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of California, San Francisco; Deutsche Forschungsgemeinschaft; Natural Sciences and Engineering Research Council of Canada; European Commission; Achievement Rewards for College Scientists Foundation; National Institutes of Health; Sandler Foundation","keywords":"Euchromatin; Heterochromatin; Biology; Subtelomere; Heterochromatin protein 1; Mating of yeast; Genetics; Nucleosome; Constitutive heterochromatin; Chromatin; Cell biology; Gene; Locus (genetics); Chromosome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008224415,0.0003409528,0.0001399085,0.0001529736,0.0001609951,0.0002419,0.0003036069,0.0002221415,0.002248253],"category_scores_gemma":[0.00005339842,0.0001458631,0.0002067847,0.00008701374,0.0002365647,0.0000897542,0.0002250736,0.0005288589,0.0004790915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003797088,"about_ca_system_score_gemma":0.0001739261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006432066,"about_ca_topic_score_gemma":0.001410189,"domain_scores_codex":[0.9998904,0.00001274823,0.000008031214,0.00002290443,0.00004056724,0.00002535574],"domain_scores_gemma":[0.9999117,0.00001108126,0.00002699682,0.0000106747,0.000006540725,0.00003307909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001643461,0.000006103477,0.00003624966,0.000005739496,0.000001019959,0.000007709274,0.000001970045,0.0000158299,0.999733,0.00003477121,0.000007548535,0.0001334749],"study_design_scores_gemma":[0.000004657839,0.00005025034,0.001779052,0.000002242477,0.000002968772,0.00005861245,0.000007732007,0.0005168933,0.9968651,0.00001669399,0.0006943544,0.000001401533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954536,0.0005393361,0.001920572,0.00008741038,0.00002221792,0.00001622224,0.0002839041,0.00008354776,0.001593264],"genre_scores_gemma":[0.9928464,0.0001983002,0.001639388,0.00004033196,0.000004515568,0.00002007383,0.0004353194,0.00003050269,0.004785115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002248253,"threshold_uncertainty_score":0.007521152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01071751924758581,"score_gpt":0.2121011263506484,"score_spread":0.2013836071030626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}