{"id":"W2944279315","doi":"10.1002/cpt.1493","title":"Shared Genetic Risk Factors Across Carbamazepine‐Induced Hypersensitivity Reactions","year":2019,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"Daiichi Sankyo Europe; European Regional Development Fund; National Institute of Allergy and Infectious Diseases; Medical Research Council; Svenska Läkaresällskapet; National Institutes of Health; Pfizer; Vetenskapsrådet; National Institute of General Medical Sciences; National Institute for Health and Care Research; University of Nottingham; Nottingham University Hospitals NHS Trust; AstraZeneca; National Institute of Diabetes and Digestive and Kidney Diseases; Instituto de Salud Carlos III; Amgen; Wellcome Trust; GlaxoSmithKline","keywords":"Carbamazepine; Hypersensitivity reaction; Delayed hypersensitivity; Medicine; Pharmacology; Epilepsy; Immunology; Psychiatry; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001380739,0.0008389334,0.001216296,0.001374289,0.0004277168,0.0009648219,0.0005016353,0.0007824502,0.002836898],"category_scores_gemma":[0.003131038,0.000394011,0.003786812,0.002414,0.0003980592,0.0003537411,0.000588712,0.0006397185,0.0001650689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002958217,"about_ca_system_score_gemma":0.0003541516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004225203,"about_ca_topic_score_gemma":0.004414655,"domain_scores_codex":[0.9980202,0.0005140285,0.0002518876,0.0008143376,0.0002399559,0.0001596374],"domain_scores_gemma":[0.9981533,0.0007837448,0.00044085,0.0003353237,0.000156913,0.0001298046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"systematic_review","study_design_scores_codex":[0.002685417,0.00009341512,0.9410768,0.0006997671,0.02735311,0.001766005,0.0002043402,0.0007183935,0.01109048,0.0004129581,0.0004799571,0.01341954],"study_design_scores_gemma":[0.0001966195,0.000261979,0.9814046,0.00009358376,0.01299921,0.001612598,0.0001299661,0.0008911649,0.001247361,0.0004016745,0.0007398858,0.00002131804],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9816212,0.01421896,0.001746197,0.0002204607,0.00007249626,0.00004751003,0.0008855298,0.00005272897,0.001134896],"genre_scores_gemma":[0.9973832,0.0013996,0.0005299009,0.00007012468,0.00002988883,0.00001819535,0.000398425,0.00001307925,0.0001576614],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.004225203,"threshold_uncertainty_score":0.00949043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3573320228502688,"score_gpt":0.5316509958784539,"score_spread":0.1743189730281851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}