{"id":"W2944306293","doi":"10.1007/s10549-019-05265-1","title":"De-escalation of bone-modifying agents in patients with bone metastases from breast cancer: a systematic review and meta-analysis","year":2019,"lang":"en","type":"review","venue":"Breast Cancer Research and Treatment","topic":"Bone health and treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Public Health; University of Ottawa; Ottawa Hospital","funders":"","keywords":"Medicine; Denosumab; Breast cancer; Meta-analysis; Randomized controlled trial; Zoledronic acid; Relative risk; Confidence interval; Internal medicine; Oncology; Dosing; Clinical trial; Cancer; Surgery; Osteoporosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005209437,0.00196388,0.01406977,0.002285637,0.0003276383,0.001816481,0.00170605,0.001856641,0.004211955],"category_scores_gemma":[0.01157002,0.001177979,0.02257319,0.002924637,0.0005133489,0.001272383,0.001125713,0.002444686,0.000287252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001801057,"about_ca_system_score_gemma":0.001682931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005992022,"about_ca_topic_score_gemma":0.02030587,"domain_scores_codex":[0.9962584,0.001539536,0.001131544,0.0004904963,0.0004045924,0.0001754323],"domain_scores_gemma":[0.9957647,0.002746641,0.001013366,0.0001508493,0.0002347697,0.00008956024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.007614163,0.00007996284,0.002496214,0.3977289,0.5642031,0.0001006825,0.00009792628,0.0006471584,0.0004247763,0.0001267836,0.0007956512,0.02568478],"study_design_scores_gemma":[0.003390211,0.0005349418,0.00342548,0.02005938,0.9698282,0.00008231263,0.00005297193,0.0001801096,0.0001174251,0.0001659056,0.002132615,0.00003041742],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005412554,0.9933622,0.0003016366,0.0001060772,0.0001369265,0.0001475695,0.000302241,0.00001898656,0.0002118421],"genre_scores_gemma":[0.199808,0.795202,0.001924145,0.001428454,0.0002140943,0.0003948342,0.0005418062,0.00003005601,0.0004565909],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01406977,"threshold_uncertainty_score":0.02755046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.216998523895043,"score_gpt":0.4619771805854899,"score_spread":0.2449786566904469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}