{"id":"W2944311490","doi":"10.1158/1538-7445.sabcs18-pd1-10","title":"Abstract PD1-10: Randomized phase II study comparing two different schedules of palbociclib plus second line endocrine therapy in women with estrogen receptor positive, HER2 negative advanced/metastatic breast cancer: CCTG MA38 (NCT02630693)","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Juravinski Cancer Centre; Université du Québec à Montréal; Ontario Institute for Cancer Research","funders":"","keywords":"Palbociclib; Medicine; Tolerability; Internal medicine; Oncology; Population; Breast cancer; Metastatic breast cancer; Tamoxifen; Cancer; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00249707,0.002197722,0.0027621,0.0005852001,0.0005554908,0.001271629,0.00162133,0.001823951,0.01353947],"category_scores_gemma":[0.002344216,0.001016981,0.001409215,0.0006418662,0.001547954,0.001154939,0.0004982306,0.004450944,0.001739687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002312245,"about_ca_system_score_gemma":0.003370634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004651874,"about_ca_topic_score_gemma":0.01258527,"domain_scores_codex":[0.9989572,0.0005707535,0.0000493847,0.0001745904,0.0001037721,0.000144333],"domain_scores_gemma":[0.9987034,0.0003009255,0.0002854142,0.00008503898,0.0001094561,0.0005159259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9720311,0.01244893,0.0005895846,0.0004893903,0.0004714304,0.00002680946,0.00003300584,0.0003724637,0.002569725,0.00007531501,0.001119324,0.009772935],"study_design_scores_gemma":[0.9180815,0.07951245,0.001209744,0.00001503918,0.000180006,0.00001403676,0.00001101915,0.0002294434,0.0001905186,0.00006520622,0.0004821471,0.000008832113],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9596885,0.00309392,0.0009538828,0.001213088,0.0007465017,0.02346038,0.005521906,0.0003012147,0.005020568],"genre_scores_gemma":[0.967865,0.001707878,0.002101111,0.001872645,0.0005272646,0.01533812,0.003903428,0.00005054492,0.006633995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01353947,"threshold_uncertainty_score":0.04529405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04480513330979158,"score_gpt":0.4114934981525055,"score_spread":0.3666883648427139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}