{"id":"W2944311490","doi":"10.1158/1538-7445.sabcs18-pd1-10","title":"Abstract PD1-10: Randomized phase II study comparing two different schedules of palbociclib plus second line endocrine therapy in women with estrogen receptor positive, HER2 negative advanced/metastatic breast cancer: CCTG MA38 (NCT02630693)","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Juravinski Cancer Centre; Université du Québec à Montréal; Ontario Institute for Cancer Research","funders":"","keywords":"Palbociclib; Medicine; Tolerability; Internal medicine; Oncology; Population; Breast cancer; Metastatic breast cancer; Tamoxifen; Cancer; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001157586,0.0006438281,0.002525236,0.0006159436,0.0001956976,0.00005067987,0.000476155,0.00006334129,0.007526373],"category_scores_gemma":[0.00008017704,0.0004647502,0.0001668961,0.00107388,0.0007782459,0.0004084018,0.0002285158,0.00119917,0.0000240052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002024332,"about_ca_system_score_gemma":0.001039971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002305618,"about_ca_topic_score_gemma":0.000963729,"domain_scores_codex":[0.9945344,0.0006464525,0.001040625,0.001031982,0.001381847,0.001364712],"domain_scores_gemma":[0.9964122,0.0009001187,0.0004659809,0.0008079837,0.0009818212,0.000431936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.768616,0.005116082,0.01936023,0.0006472517,0.002665473,0.0001132938,0.008643947,0.002467849,0.09285336,0.00006221519,0.00002479318,0.0994295],"study_design_scores_gemma":[0.8484159,0.009793452,0.04055681,0.002894441,0.0001281551,0.00004339659,0.01257978,0.0005775742,0.08356029,0.0003270445,0.0003065511,0.0008166861],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986811,0.004439428,0.000030455,0.0007003764,0.0001643296,0.007101096,0.0004721349,0.00006510899,0.0002160518],"genre_scores_gemma":[0.9922842,0.001366325,0.0004611351,0.00008518745,0.0001972803,0.004000933,0.00004554241,0.0001520545,0.001407303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09861281,"threshold_uncertainty_score":0.9997804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04480513330979158,"score_gpt":0.4114934981525055,"score_spread":0.3666883648427139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}