{"id":"W2944327584","doi":"10.1158/1538-7445.sabcs18-p1-16-03","title":"Abstract P1-16-03: Phase II randomized clinical trial (RCT) of metformin (MET) vs placebo (PLAC) in combination with chemotherapy (CXT) in refractory locally advanced (LABC) or metastatic breast cancer (MBC)","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Princess Margaret Cancer Centre; University Health Network; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; St. Michael's Hospital","funders":"","keywords":"Medicine; Internal medicine; Vinorelbine; Taxane; Breast cancer; Anthracycline; Placebo; Cancer; Gastroenterology; Capecitabine; Progression-free survival; Oncology; Surgery; Chemotherapy; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003193761,0.00330751,0.004739845,0.0007344679,0.0007901472,0.001996292,0.001440677,0.003524946,0.02251738],"category_scores_gemma":[0.003000129,0.001123109,0.002568068,0.0006630357,0.001887397,0.001813016,0.000833795,0.005560404,0.003651066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009631807,"about_ca_system_score_gemma":0.001771546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009125029,"about_ca_topic_score_gemma":0.001548486,"domain_scores_codex":[0.9988291,0.0006574907,0.00008648184,0.0002032683,0.0000664387,0.0001572737],"domain_scores_gemma":[0.9981741,0.000418798,0.0004625613,0.0001434385,0.0001528726,0.0006482954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9877781,0.005437607,0.0001462795,0.0007537539,0.0004902963,0.00002604316,0.00002344123,0.0001043022,0.001201856,0.00007102873,0.000588146,0.00337904],"study_design_scores_gemma":[0.9657915,0.03313054,0.0002585121,0.00002833694,0.0001865468,0.000009965166,0.000008969013,0.00009047332,0.0001054761,0.00007480315,0.0003099422,0.000004998487],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9176595,0.007026708,0.001645201,0.003422795,0.002535838,0.05406665,0.006290308,0.0006796977,0.006673296],"genre_scores_gemma":[0.9074017,0.004167398,0.005059518,0.003891224,0.001624082,0.05999245,0.003405644,0.0001038406,0.01435411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02251738,"threshold_uncertainty_score":0.07532817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0490663747175627,"score_gpt":0.4299014474251756,"score_spread":0.3808350727076129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}