{"id":"W2944330168","doi":"10.1016/j.chom.2019.04.002","title":"Bacteroides-Derived Sphingolipids Are Critical for Maintaining Intestinal Homeostasis and Symbiosis","year":2019,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":551,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; American Diabetes Association; Canadian Institutes of Health Research; University of British Columbia; Broad Institute; Crohn's and Colitis Foundation; National Center for Complementary and Integrative Health; Richard and Susan Smith Family Foundation; Joslin Diabetes Center; National Institutes of Health; Massachusetts General Hospital; Crohn's and Colitis Foundation of America","keywords":"Sphingolipid; Bacteroides thetaiotaomicron; Biology; Ceramide; Sphingosine; Bacteroides; Gut flora; Inflammation; Lipid signaling; Microbiology; Cell biology; Metabolomics; Biochemistry; Bacteria; Immunology; Genetics; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002601783,0.0005136925,0.0002217333,0.000271248,0.0003710319,0.0007195021,0.0001843882,0.0004628795,0.0008401786],"category_scores_gemma":[0.0002719427,0.00020877,0.0001660841,0.0001716614,0.0002782707,0.0004141949,0.0007076086,0.0005216636,0.0005869919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005005035,"about_ca_system_score_gemma":0.0004569235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001082273,"about_ca_topic_score_gemma":0.001388085,"domain_scores_codex":[0.9997976,0.0000340749,0.00001412007,0.00004105399,0.00005559799,0.00005762923],"domain_scores_gemma":[0.9997804,0.00001277314,0.00005630821,0.00001423434,0.00003632003,0.00009999222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000155991,0.000004059474,0.0005274605,0.00002192707,0.000002312143,0.00009396936,0.00001121253,0.00002192498,0.9979244,0.0001541491,0.00003674818,0.001045914],"study_design_scores_gemma":[0.00003706965,0.0002429489,0.04396866,0.00002781795,0.00003238685,0.00100554,0.000296763,0.001167871,0.9446408,0.0006746894,0.007881925,0.00002351078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781319,0.007036503,0.008313647,0.0006221209,0.0001165283,0.00003529117,0.0005989886,0.0002975066,0.004847546],"genre_scores_gemma":[0.9944538,0.0007763359,0.002531043,0.00005902578,0.00001215148,0.00001170124,0.0002918152,0.0000176239,0.001846377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001082273,"threshold_uncertainty_score":0.003631413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008172991096983944,"score_gpt":0.2384659258376869,"score_spread":0.2302929347407029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}