{"id":"W2944353738","doi":"10.3390/biom9050184","title":"Histone Deacetylase Inhibitors Dose-Dependently Switch Neutrophil Death from NETosis to Apoptosis","year":2019,"lang":"en","type":"article","venue":"Biomolecules","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; University of Toronto; Cystic Fibrosis Canada","keywords":"Panobinostat; Neutrophil extracellular traps; Histone deacetylase; Acetylation; Apoptosis; Histone; Cancer research; Chemistry; Medicine; Immunology; Biochemistry; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001368754,0.0004692842,0.0005394585,0.0002807034,0.0001974454,0.00005237034,0.0005210347,0.0003538111,0.001493761],"category_scores_gemma":[0.00002601805,0.0004208505,0.00022879,0.0003310457,0.0001039334,0.0001433411,0.0003182646,0.000295894,0.01290475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001453817,"about_ca_system_score_gemma":0.00007243199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001456305,"about_ca_topic_score_gemma":0.0000587165,"domain_scores_codex":[0.9976315,0.0002157733,0.000448208,0.0008995333,0.0001198969,0.0006851046],"domain_scores_gemma":[0.9988019,0.0000924888,0.0001488506,0.0007211557,0.0001075765,0.0001279709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002798588,0.0001795968,0.0007914888,0.00001040322,0.0001973457,0.00001630941,0.0002308183,0.000004300731,0.9910427,0.001952979,0.003170675,0.002123536],"study_design_scores_gemma":[0.001716856,0.0004565844,0.002879223,0.00005894191,0.00008441458,0.00001288079,0.000233036,0.000001151671,0.970823,0.0002473948,0.02295988,0.0005266678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930348,0.001525888,0.000442395,0.001153192,0.001676813,0.0008210933,0.0001531359,0.0002186282,0.0009739994],"genre_scores_gemma":[0.9947384,0.00007345078,0.0007458538,0.001540291,0.0001246408,0.00009450423,0.0002337017,0.0000789308,0.002370232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02021972,"threshold_uncertainty_score":0.9998243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01246493284502007,"score_gpt":0.2494377486274247,"score_spread":0.2369728157824046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}