{"id":"W2944353738","doi":"10.3390/biom9050184","title":"Histone Deacetylase Inhibitors Dose-Dependently Switch Neutrophil Death from NETosis to Apoptosis","year":2019,"lang":"en","type":"article","venue":"Biomolecules","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; University of Toronto; Cystic Fibrosis Canada","keywords":"Panobinostat; Neutrophil extracellular traps; Histone deacetylase; Acetylation; Apoptosis; Histone; Cancer research; Chemistry; Medicine; Immunology; Biochemistry; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002094974,0.0004499348,0.0005533561,0.0002487454,0.0001364655,0.0003076697,0.0003510568,0.0003772941,0.003066691],"category_scores_gemma":[0.0002001129,0.0001991964,0.0003606841,0.0002899247,0.0002875353,0.0002643818,0.0002314561,0.001261165,0.0004903902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000366515,"about_ca_system_score_gemma":0.000411926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006966611,"about_ca_topic_score_gemma":0.001559604,"domain_scores_codex":[0.999673,0.00005002796,0.00004541452,0.00006830016,0.00006776464,0.00009551479],"domain_scores_gemma":[0.999854,0.00003365638,0.00002757699,0.0000186528,0.00001782431,0.00004830478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002181628,0.000732487,0.0002431261,0.0001542827,0.00004158688,0.00007735715,0.00004265261,0.0001821438,0.9906369,0.0001698988,0.000462658,0.005075295],"study_design_scores_gemma":[0.0003264085,0.005672508,0.003412817,0.0000134866,0.00004795582,0.0001694553,0.00004671546,0.001061327,0.985921,0.00008351018,0.003232392,0.00001242387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883261,0.003785165,0.00222531,0.0004051693,0.0003702105,0.0001882936,0.0009879279,0.00025342,0.003458373],"genre_scores_gemma":[0.9880983,0.002277367,0.003009863,0.0003108591,0.00006872199,0.000218059,0.001584969,0.00002784588,0.00440401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003066691,"threshold_uncertainty_score":0.01025909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01246493284502007,"score_gpt":0.2494377486274247,"score_spread":0.2369728157824046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}