{"id":"W2944354478","doi":"10.3389/fimmu.2019.01026","title":"Autoantibodies in Systemic Lupus Erythematosus Target Mitochondrial RNA","year":2019,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Autoantibody; Mitochondrial DNA; Immunology; Mitochondrion; Antibody; Lupus erythematosus; Biology; Immune system; Autoimmunity; Molecular biology; RNA; Medicine; Gene; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003157953,0.0003934156,0.0001903382,0.0006861018,0.00013756,0.000279302,0.000096108,0.0002609086,0.001727889],"category_scores_gemma":[0.000514401,0.0001278127,0.0001898634,0.0003182823,0.0001499252,0.0001297714,0.0001723172,0.0003147793,0.0002983732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001945342,"about_ca_system_score_gemma":0.00009933196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003486882,"about_ca_topic_score_gemma":0.000283911,"domain_scores_codex":[0.9997055,0.00008679587,0.00003807423,0.00005994752,0.00008758815,0.00002217388],"domain_scores_gemma":[0.9994478,0.00008884618,0.000323015,0.00002959364,0.00004582949,0.00006489713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001256875,0.0002100727,0.3416817,0.0004145073,0.0002831653,0.00334247,0.0003944535,0.000437446,0.5936273,0.0004510976,0.001043376,0.0568576],"study_design_scores_gemma":[0.00007640519,0.001162413,0.9495534,0.00007229995,0.0001741561,0.01239654,0.0001252913,0.001172784,0.02922998,0.0004890655,0.005533225,0.00001448749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926518,0.003643149,0.001069002,0.0001284409,0.00002804012,0.0000182153,0.0001565242,0.00008934789,0.002215393],"genre_scores_gemma":[0.9977731,0.000740721,0.0006245571,0.00006519126,0.00003738028,0.00001160325,0.0001283491,0.000005688574,0.0006134214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001727889,"threshold_uncertainty_score":0.005780339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009700453828552844,"score_gpt":0.2572241380395626,"score_spread":0.2475236842110098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}