{"id":"W2944446355","doi":"10.1001/jamapsychiatry.2019.0779","title":"Efficacy of Adjunctive Infliximab vs Placebo in the Treatment of Adults With Bipolar I/II Depression","year":2019,"lang":"en","type":"article","venue":"JAMA Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University Health Network; University of Toronto","funders":"Daiichi Sankyo Europe; National Institute on Drug Abuse; Pfizer; National Institute of Mental Health; National Institutes of Health; Allergan; Sunovion; Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Palo Alto Health Sciences; H. Lundbeck A/S; Stanley Medical Research Institute; Purdue University","keywords":"Infliximab; Medicine; Randomized controlled trial; Bipolar disorder; Internal medicine; Depression (economics); Placebo; Adjunctive treatment; Bipolar II disorder; Montgomery–Åsberg Depression Rating Scale; Major depressive episode; Psychiatry; Placebo-controlled study; Pediatrics; Physical therapy; Mood; Major depressive disorder; Double blind; Tumor necrosis factor alpha","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001869822,0.0007055535,0.002361899,0.0003592005,0.0003522685,0.0007125462,0.0004934709,0.001045963,0.00331614],"category_scores_gemma":[0.003023474,0.0003817124,0.001179787,0.0003514071,0.0005208945,0.0006475235,0.0003042142,0.001557224,0.000362685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004035742,"about_ca_system_score_gemma":0.0005032015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004338244,"about_ca_topic_score_gemma":0.001507916,"domain_scores_codex":[0.9990362,0.0006085781,0.0001220477,0.00009346186,0.0000790448,0.00006064408],"domain_scores_gemma":[0.9988443,0.0004199814,0.0003648682,0.00004865346,0.00007272604,0.0002495174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8947457,0.005721581,0.002937113,0.001383081,0.001517418,0.00005579579,0.00009511464,0.0001907533,0.00284575,0.00007292247,0.0005325245,0.0899023],"study_design_scores_gemma":[0.7325097,0.2418585,0.01988094,0.0003396974,0.002140766,0.0001093425,0.00008795783,0.0007009203,0.0007437995,0.0002243958,0.001384365,0.00001961648],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9659838,0.0284601,0.0003966955,0.0007850729,0.0006166532,0.001284601,0.0003237453,0.00006235836,0.002087047],"genre_scores_gemma":[0.9891071,0.007252655,0.0008169196,0.0007006842,0.0004559995,0.0008369545,0.0002023019,0.000004712482,0.0006228286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00331614,"threshold_uncertainty_score":0.01109356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008208050681070542,"score_gpt":0.2365279630168468,"score_spread":0.2283199123357763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}