{"id":"W2944455963","doi":"10.1016/j.celrep.2019.04.034","title":"The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; SickKids Foundation; University of Toronto; University Health Network; Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Cystic Fibrosis Canada; Canada Foundation for Innovation; Common Fund for Commodities; CRC Health Group","keywords":"mTORC1; Cell biology; Regulator; Cell growth; Intracellular; MAPK/ERK pathway; Chemistry; Cell; Cotransporter; Transporter; PI3K/AKT/mTOR pathway; Biology; Signal transduction; Biochemistry; Sodium; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002620193,0.0001988917,0.0001660506,0.00002260139,0.0001242319,0.00005866843,0.000143471,0.0003200724,0.00009060363],"category_scores_gemma":[0.000007901581,0.000158733,0.0001309294,0.00006267581,0.00003286219,0.000008177878,0.000043241,0.0001635761,0.00005246709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001440553,"about_ca_system_score_gemma":0.00005731921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001571819,"about_ca_topic_score_gemma":0.000003047974,"domain_scores_codex":[0.9985141,0.00003722876,0.0003812604,0.0005061204,0.0002098055,0.0003514805],"domain_scores_gemma":[0.9988136,0.000007344446,0.0002177122,0.000745124,0.0000777122,0.0001384629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002386777,0.00003057831,0.00282732,0.00002467755,0.000005194346,0.00001233432,0.00007891581,0.0002261888,0.9675543,0.000001236607,0.02817554,0.001039793],"study_design_scores_gemma":[0.0001303257,0.00004520547,0.001192806,0.00000441898,0.00001523764,0.000007266294,0.0000267819,0.00002909439,0.5485604,0.00002120988,0.4498327,0.0001345514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738146,0.002414864,0.004563585,0.0001169795,0.001032617,0.0003841621,0.000008613259,0.00002050081,0.01764407],"genre_scores_gemma":[0.897077,0.0001376441,0.0004118552,0.0002244389,0.0002938614,0.00001486899,0.0002347401,0.00004003088,0.1015655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4216572,"threshold_uncertainty_score":0.6472943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002847608070475318,"score_gpt":0.1891234589089663,"score_spread":0.1862758508384909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}