{"id":"W2944455963","doi":"10.1016/j.celrep.2019.04.034","title":"The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; SickKids Foundation; University of Toronto; University Health Network; Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Cystic Fibrosis Canada; Canada Foundation for Innovation; Common Fund for Commodities; CRC Health Group","keywords":"mTORC1; Cell biology; Regulator; Cell growth; Intracellular; MAPK/ERK pathway; Chemistry; Cell; Cotransporter; Transporter; PI3K/AKT/mTOR pathway; Biology; Signal transduction; Biochemistry; Sodium; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002306074,0.0003133588,0.0003722945,0.0003282164,0.0003203572,0.0009269031,0.0003141494,0.0003372682,0.001104812],"category_scores_gemma":[0.0004872966,0.0001862758,0.0002325478,0.0002205855,0.0006245941,0.0008002761,0.0005105978,0.000617868,0.0003884571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008055369,"about_ca_system_score_gemma":0.0004316692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001295369,"about_ca_topic_score_gemma":0.001289487,"domain_scores_codex":[0.9997997,0.00002650622,0.00001898201,0.00005265966,0.00006660793,0.00003559534],"domain_scores_gemma":[0.9997235,0.00003083924,0.00009313195,0.00001919778,0.00007381994,0.00005959757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000346615,0.00002226501,0.002379529,0.0001670288,0.00003470958,0.0002128776,0.00005512109,0.0003449933,0.9820217,0.00365614,0.0009203836,0.009838669],"study_design_scores_gemma":[0.00004994393,0.0002150527,0.02901663,0.00002180152,0.00004939711,0.0009573281,0.0001067716,0.002340133,0.9420528,0.001993427,0.02316308,0.00003364143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9219695,0.032464,0.0274787,0.003403706,0.0007071382,0.00005113272,0.001013667,0.0006012081,0.01231096],"genre_scores_gemma":[0.9853026,0.006693248,0.003254777,0.0002487233,0.0001393454,0.00002973062,0.0004727607,0.00006116003,0.003797759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001295369,"threshold_uncertainty_score":0.005844653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002847608070475318,"score_gpt":0.1891234589089663,"score_spread":0.1862758508384909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}