{"id":"W2944460071","doi":"10.1016/j.jalz.2019.01.012","title":"Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH‐EXAMINER as a potential clinical trial endpoint","year":2019,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Occupational Cancer Research Centre; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute on Aging; Janssen Pharmaceuticals; Alzheimer Society of B.C.; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; University of California, San Diego; GE Healthcare; Eisai; Parkinsonfonden; University of California, San Francisco; Alzheimer Society; TauRx Pharmaceuticals; Puma Biotechnology; AbbVie; Teva Pharmaceutical Industries; Pfizer; Biogen; University of Pennsylvania; New York State Department of Health; Wyeth; University of Southern California; Roche; Centers for Disease Control and Prevention; Novartis; National Institutes of Health; Association for Frontotemporal Degeneration; Merck; Alzheimer's Drug Discovery Foundation; U.S. Department of Defense; Eli Lilly and Company; BrightFocus Foundation; Allergan; AstraZeneca; Bristol-Myers Squibb; Alzheimer's Association; Huntington's Disease Society of America; Genentech; Larry L. Hillblom Foundation; Michael J. Fox Foundation for Parkinson's Research","keywords":"Frontotemporal dementia; Frontotemporal lobar degeneration; C9orf72; Clinical Dementia Rating; Dementia; Rating scale; Neuropsychology; Medicine; Psychology; Clinical trial; Executive dysfunction; Cognition; Disease; Psychiatry; Oncology; Internal medicine; Developmental psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01337147,0.0005939713,0.001280969,0.0004018419,0.0003873513,0.0008923273,0.0004148218,0.001073818,0.00166341],"category_scores_gemma":[0.006961874,0.0001649959,0.00112692,0.0004212927,0.0003365661,0.000566806,0.0003672095,0.0006655605,0.0003129137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003096065,"about_ca_system_score_gemma":0.0006308005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002470366,"about_ca_topic_score_gemma":0.000748504,"domain_scores_codex":[0.9947961,0.003903446,0.0004812159,0.0002876701,0.0003859966,0.0001455884],"domain_scores_gemma":[0.9939187,0.002375749,0.00210678,0.000367655,0.0006722403,0.0005589304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5787123,0.005344901,0.3188927,0.002121847,0.00734166,0.0002149629,0.0003290553,0.001230494,0.004259222,0.0005401127,0.002014081,0.07899858],"study_design_scores_gemma":[0.06825761,0.1396948,0.7721119,0.0004521871,0.00463813,0.0005123118,0.000130064,0.002889615,0.004484622,0.001380848,0.005365407,0.0000825497],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835353,0.006480165,0.001109168,0.0003828598,0.0001195056,0.002196928,0.001323274,0.00004933804,0.004803559],"genre_scores_gemma":[0.9922205,0.0006609335,0.001219384,0.0002854815,0.0001196814,0.00377719,0.0008885125,0.000006543503,0.0008218275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01337147,"threshold_uncertainty_score":0.0707159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04409242302797314,"score_gpt":0.360980869396488,"score_spread":0.3168884463685149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}