{"id":"W2944508336","doi":"10.1093/gigascience/giz055","title":"A highly predictive signature of cognition and brain atrophy for progression to Alzheimer's dementia","year":2019,"lang":"en","type":"article","venue":"GigaScience","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; Institut Universitaire en Santé Mentale de Québec; Université de Montréal; Institut Universitaire de Gériatrie de Montréal; McGill University; Douglas Mental Health University Institute","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institutes of Health; Northern California Institute for Research and Education; Novartis Pharmaceuticals Corporation; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Canadian Institutes of Health Research; University of Southern California; National Institute on Aging; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Dementia; Neuroimaging; Cognition; Atrophy; Alzheimer's disease; Disease; Medicine; Intervention (counseling); Psychology; Clinical psychology; Cognitive psychology; Psychiatry; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003529735,0.00008257226,0.0001387291,0.0001218316,0.00006121642,0.00001937515,0.00007901082,0.00004204129,0.00005527249],"category_scores_gemma":[0.000107206,0.00006411557,0.00004079208,0.000272519,0.0001167669,0.0001300325,0.00007524679,0.00007302198,0.00001412456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008560884,"about_ca_system_score_gemma":0.00008403246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002745686,"about_ca_topic_score_gemma":6.915936e-7,"domain_scores_codex":[0.9988844,0.00002489753,0.0001287437,0.0002984975,0.000424911,0.0002385718],"domain_scores_gemma":[0.999344,0.00007645808,0.00005092009,0.0001100213,0.0002753975,0.0001432406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001215392,0.0002775895,0.06647673,0.0001763949,0.000258656,0.000006099176,0.0005361594,0.00000258706,0.8805946,0.0003199731,0.001595077,0.04854079],"study_design_scores_gemma":[0.004241765,0.01217617,0.4551239,0.0006305184,0.000562966,0.00001884191,0.0005270686,0.001377251,0.5217492,0.0007786611,0.002599899,0.0002137353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898691,0.0005978541,0.004165328,0.001516048,0.0000798033,0.002311806,0.00003024435,0.0000215558,0.001408229],"genre_scores_gemma":[0.9957365,0.00000863662,0.00347798,0.00050528,0.00003010616,0.0001109831,0.00001701635,0.000007062401,0.0001064299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3886472,"threshold_uncertainty_score":0.2614557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01371613905705453,"score_gpt":0.321504967140659,"score_spread":0.3077888280836044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}