{"id":"W2944535240","doi":"10.1016/j.bbmt.2019.05.007","title":"Impact of T Cell Dose on Outcome of T Cell-Replete HLA-Matched Allogeneic Peripheral Blood Stem Cell Transplantation","year":2019,"lang":"en","type":"article","venue":"Biology of Blood and Marrow Transplantation","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Office of Naval Research; Pharmacyclics; Kite Pharma; Health Resources and Services Administration; Swedish Orphan Biovitrum; Janssen Scientific Affairs; Mundipharma EDO; Astellas Pharma; Adaptive Biotechnologies; bluebird bio; Chimerix; Medical College of Wisconsin; Takeda Oncology; University of Minnesota; Karyopharm Therapeutics; U.S. Navy; Celgene; U.S. Public Health Service; U.S. Department of Defense; Sanofi; U.S. Department of Health and Human Services; Astellas Pharma US; HistoGenetics; Sanofi Genzyme; Patient-Centered Outcomes Research Institute; Bristol-Myers Squibb; Medac; Jazz Pharmaceuticals; Be The Match Foundation; Spectrum Pharmaceuticals; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Incyte; Pfizer; Amgen; Atara Biotherapeutics; National Cancer Institute; Gilead Sciences","keywords":"Medicine; Cumulative incidence; Transplantation; Gastroenterology; Internal medicine; Stem cell; CD3; Univariate analysis; Immunology; Hematopoietic stem cell transplantation; Human leukocyte antigen; Oncology; CD8; Immune system; Multivariate analysis; Antigen; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009122155,0.0003029933,0.0008092425,0.0003494874,0.0001816925,0.0007430324,0.0004906118,0.000526576,0.002072138],"category_scores_gemma":[0.00100907,0.0001149437,0.0002515791,0.0002890939,0.0004735084,0.000396547,0.0003003035,0.001303751,0.0002916041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001866472,"about_ca_system_score_gemma":0.0003223735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002133102,"about_ca_topic_score_gemma":0.0002962202,"domain_scores_codex":[0.9993328,0.0003175948,0.00005559201,0.00007071855,0.00008933389,0.0001338544],"domain_scores_gemma":[0.9990239,0.0004796727,0.0001258954,0.0001106107,0.00003550238,0.0002244355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.159433,0.01261076,0.0118521,0.0002480053,0.000384972,0.0009141485,0.0003981828,0.004876958,0.7381039,0.001310212,0.001007101,0.06886074],"study_design_scores_gemma":[0.005138354,0.2018683,0.08004874,0.0001192338,0.001263258,0.002063083,0.0004611591,0.006883765,0.6946634,0.001600176,0.005810612,0.0000799201],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979891,0.0007351445,0.0002152558,0.00005121919,0.00004897242,0.00003007798,0.00008946093,0.00001256507,0.0008282227],"genre_scores_gemma":[0.9988552,0.0002380826,0.0001552552,0.00006053822,0.00004460842,0.0000247598,0.0001568216,0.00000954296,0.0004550469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002072138,"threshold_uncertainty_score":0.006931961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0153351704604505,"score_gpt":0.2652709115635201,"score_spread":0.2499357411030696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}