{"id":"W2944582362","doi":"10.1056/nejmoa1901981","title":"Placebo-Controlled Trial of an Oral BTK Inhibitor in Multiple Sclerosis","year":2019,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":320,"is_retracted":false,"has_abstract":true,"ca_institutions":"NeuroRx Research (Canada); University of Toronto; St. Michael's Hospital","funders":"Merck KGaA","keywords":"Placebo; Multiple sclerosis; Medicine; Bruton's tyrosine kinase; Internal medicine; Clinical trial; Oncology; Pharmacology; Alternative medicine; Immunology; Pathology; Tyrosine kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001699147,0.001479446,0.004131489,0.0005801672,0.0005148702,0.00125432,0.0008335682,0.002395647,0.01341673],"category_scores_gemma":[0.001937218,0.0005172045,0.001456673,0.0004681571,0.001040466,0.001167787,0.0004105776,0.002765635,0.00151474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007166953,"about_ca_system_score_gemma":0.001039135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007715597,"about_ca_topic_score_gemma":0.001559986,"domain_scores_codex":[0.9992355,0.0003681484,0.00006869629,0.0001553826,0.00006730195,0.000104919],"domain_scores_gemma":[0.9991823,0.0002282744,0.0001832376,0.0000482289,0.00007674252,0.0002812766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9821331,0.002224085,0.0002118401,0.0009691784,0.000679276,0.00003821146,0.00001810416,0.0001292219,0.001034384,0.0000948467,0.0008973317,0.01157039],"study_design_scores_gemma":[0.9634924,0.03353767,0.001176125,0.0000650861,0.0003130414,0.00002713915,0.00001346782,0.0001777916,0.0001507254,0.0001120717,0.0009277569,0.000006786514],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9310045,0.04007076,0.001189274,0.003467776,0.004285216,0.006857395,0.002957618,0.0005245756,0.009642853],"genre_scores_gemma":[0.9728585,0.007937401,0.001421224,0.002779661,0.001439931,0.005604498,0.001691465,0.00003304178,0.00623419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01341673,"threshold_uncertainty_score":0.04488343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04527378136246739,"score_gpt":0.3088913223947608,"score_spread":0.2636175410322934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}