{"id":"W2944600762","doi":"10.1053/j.gastro.2019.05.004","title":"Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia","year":2019,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":232,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia; Pancreas Centre (Canada); Vancouver General Hospital","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; VGH and UBC Hospital Foundation; University of Pennsylvania","keywords":"Hypoxia (environmental); KRAS; Carbonic anhydrase; Pancreatic cancer; Cancer research; Chemistry; Cancer; Internal medicine; Medicine; Biochemistry; Enzyme; Oxygen; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007868376,0.0001533144,0.0001882031,0.00009137132,0.0001613883,0.0002601458,0.000110682,0.0001662221,0.0009779274],"category_scores_gemma":[0.00008591967,0.00008227224,0.0002081514,0.0001013624,0.0001480833,0.0001621226,0.0001742896,0.0003610117,0.0001811524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002742525,"about_ca_system_score_gemma":0.0001518592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006877279,"about_ca_topic_score_gemma":0.0009536457,"domain_scores_codex":[0.999915,0.00001192306,0.000007326197,0.00001703043,0.00002103809,0.00002778488],"domain_scores_gemma":[0.9999245,0.000009338439,0.00002254223,0.000008497427,0.000009826656,0.00002526344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002981573,0.0000256906,0.0009949025,0.00002866229,0.000005901697,0.00006267677,0.00001389239,0.00007951466,0.9974496,0.00005854745,0.00008885519,0.0008935491],"study_design_scores_gemma":[0.00003155466,0.000382607,0.03395156,0.00000897792,0.00001854448,0.0003600921,0.00009001491,0.002040108,0.9599437,0.00006313,0.003103638,0.000006044321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997338,0.0007067081,0.0007153468,0.000113085,0.0000166822,0.000009769768,0.0003039089,0.00003096664,0.0007655355],"genre_scores_gemma":[0.9979596,0.000402836,0.0003997112,0.00003282207,0.000004992444,0.00002066624,0.0003624824,0.000005982682,0.0008108626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009779274,"threshold_uncertainty_score":0.00327152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004139706509256099,"score_gpt":0.2104035935554428,"score_spread":0.2062638870461867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}