{"id":"W2944669799","doi":"10.1111/jdv.15668","title":"Use of dose–exposure–response relationships in Phase 2 and Phase 3 guselkumab studies to optimize dose selection in psoriasis","year":2019,"lang":"en","type":"article","venue":"Journal of the European Academy of Dermatology and Venereology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Janssen Research and Development","keywords":"Medicine; Psoriasis; Selection (genetic algorithm); Phase (matter); Dermatology; Machine learning","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1006479,0.001581005,0.002073058,0.001470914,0.0006431398,0.002136111,0.001444292,0.001647554,0.002646377],"category_scores_gemma":[0.04976479,0.000776468,0.003398818,0.001596564,0.0005734562,0.001619166,0.001119014,0.00270489,0.0007767074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001748485,"about_ca_system_score_gemma":0.002590081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002892549,"about_ca_topic_score_gemma":0.0006337889,"domain_scores_codex":[0.9290249,0.05853389,0.003746196,0.002074081,0.005409009,0.001211868],"domain_scores_gemma":[0.9378754,0.03231923,0.01916114,0.004688346,0.004467745,0.001488166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3646026,0.02249143,0.1647081,0.002631948,0.009837372,0.0002833099,0.001404064,0.01910122,0.07098465,0.001766851,0.005847236,0.3363413],"study_design_scores_gemma":[0.0564248,0.4371555,0.377221,0.0005447075,0.006683622,0.0007111005,0.0002579375,0.0261668,0.05196777,0.002226855,0.0403343,0.0003056324],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8487253,0.02242354,0.06206936,0.001344621,0.0004783189,0.04636114,0.003237042,0.00141462,0.01394601],"genre_scores_gemma":[0.935455,0.001434282,0.03766929,0.001162139,0.0001854779,0.02134316,0.001173326,0.0002569349,0.001320503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1006479,"threshold_uncertainty_score":0.5322831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06422691084866118,"score_gpt":0.3138603410601825,"score_spread":0.2496334302115213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}