{"id":"W2944669903","doi":"10.1101/632331","title":"DEAD-box protein family member DDX28 is a negative regulator of HIF-2α and eIF4E2-directed hypoxic translation","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Regulator; Cell biology; Downregulation and upregulation; Biology; Gene silencing; Translation (biology); Transcription (linguistics); Transcription factor; Polysome; Psychological repression; Messenger RNA; Molecular biology; Gene expression; Genetics; RNA; Gene; Ribosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009526673,0.000266144,0.0002286854,0.000115687,0.0001706367,0.000168577,0.0001276983,0.0001540074,0.001491226],"category_scores_gemma":[0.00008211783,0.000095411,0.000160326,0.00007676451,0.0001515827,0.0001028373,0.0001982993,0.0002231352,0.0005471245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002145536,"about_ca_system_score_gemma":0.00009345198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001245005,"about_ca_topic_score_gemma":0.0001519858,"domain_scores_codex":[0.999897,0.00001092648,0.00001006402,0.00003684559,0.00003274403,0.00001248071],"domain_scores_gemma":[0.9999127,0.00001178119,0.00003564227,0.000008592418,0.000009651403,0.0000215961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003709782,0.000007088906,0.0002434651,0.0000271287,0.000002997578,0.00004972776,0.000005537223,0.00004036035,0.9985342,0.00007278615,0.00007269382,0.0009068294],"study_design_scores_gemma":[0.00001037866,0.00007251152,0.006439319,0.000004579802,0.000006864006,0.000619015,0.00001592556,0.001431132,0.9855176,0.00004801338,0.005831529,0.000003275273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828681,0.003050282,0.01130566,0.0001336663,0.00008429345,0.00002805753,0.0007833286,0.000198764,0.001547957],"genre_scores_gemma":[0.9894846,0.0005254882,0.003556306,0.00004932599,0.0000116644,0.00003221712,0.001033336,0.00002306119,0.005283893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001491226,"threshold_uncertainty_score":0.004988611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01678914938467534,"score_gpt":0.2287591320741259,"score_spread":0.2119699826894505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}