{"id":"W2944717492","doi":"10.1158/1538-7445.sabcs18-ot1-06-01","title":"Abstract OT1-06-01: ANG1005 in leptomeningeal disease (ANGLeD) trial: A randomized, open-label, phase 3 study of ANG1005 compared with Physician's Best Choice in HER2-negative breast cancer patients with newly diagnosed leptomeningeal carcinomatosis and previously treated brain metastases","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Angiochem (Canada)","funders":"","keywords":"Medicine; Breast cancer; Internal medicine; Capecitabine; Metastatic breast cancer; Cancer; Oncology; Eribulin; Chemotherapy; Phases of clinical research; Gastroenterology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001540888,0.0005756957,0.002213771,0.0006967693,0.0001238448,0.0001417959,0.0003519368,0.00007600258,0.0002371375],"category_scores_gemma":[0.0001998219,0.0003918622,0.00008623546,0.001669948,0.0004719383,0.0004708272,0.0002117867,0.0005897387,0.000006230258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008279906,"about_ca_system_score_gemma":0.001022318,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.08655213,"about_ca_topic_score_gemma":0.02736094,"domain_scores_codex":[0.9943492,0.001388049,0.0008184527,0.001121294,0.001307065,0.001015969],"domain_scores_gemma":[0.9961695,0.001684832,0.0004032221,0.0006342457,0.0005230288,0.0005851892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.50394,0.018267,0.4701598,0.0003430899,0.0009334057,0.0002777999,0.002558381,0.0001246838,0.0001096854,0.000003359635,0.0001713916,0.003111439],"study_design_scores_gemma":[0.6663479,0.006523126,0.3224386,0.001538728,0.0005022981,0.000001981665,0.002029294,0.0001106908,0.0001743884,0.00000314195,0.0000259321,0.0003039316],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782544,0.001155112,6.422066e-7,0.00050499,0.00003394593,0.0189313,0.001027603,0.00002616267,0.00006580428],"genre_scores_gemma":[0.9928381,0.000163178,0.00008883107,0.00008352102,0.00007593136,0.006279312,0.0002471738,0.0001039205,0.0001200571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1624079,"threshold_uncertainty_score":0.9998533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05972211473529758,"score_gpt":0.4029597303643158,"score_spread":0.3432376156290182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}